diethyl 5-nitrosoisophthalate | 365549-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 5-nitrosoisophthalate
• 英文别名: Diethyl 5-nitrosobenzene-1,3-dicarboxylate
• CAS: 365549-28-6
• 化学式: C₁₂H₁₃NO₅
• 分子量: 251.239
• InChiKey: PZEUKGGYPJMQOV-UHFFFAOYSA-N

物化性质

• 沸点：
  382.6±32.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  82
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  diethyl 5-nitrosoisophthalate 在 一水合肼 、 溶剂黄146 作用下， 以 甲醇 、 二氯甲烷 、 氘代甲苯 为溶剂， 反应 30.0h， 生成 (Z)-diethyl 5-((3-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)phenyl)diazenyl)isophthalate
  参考文献：
  名称：

  Photoswitchable Thioureas for the External Manipulation of Catalytic Activity

  摘要：

  A series of azobenzene-based thiourea catalysts have been developed with the aim of achieving control over the catalytic activity by the use of light. The conceptual design of these systems relies on the inactivation by means of intramolecular hydrogen bonding, only likely to take place in one of their isomeric forms. After fine structure modulation of the catalyst a substantial difference in activity has been observed between the irradiated and the nonirradiated reaction. Furthermore, the system allowed in situ manipulation of the catalyst activity during the course of a given experiment.

  DOI：

  10.1021/ol500381c
• 作为产物：
  描述：

  5-硝基间苯二甲酸二乙酯 在 ammonium chloride 、 三氯化铁 、 锌 作用下， 以 乙醇 、 乙二醇甲醚 、 水 为溶剂， 反应 1.0h， 生成 diethyl 5-nitrosoisophthalate
  参考文献：
  名称：

  具有全偶氮苯重复单元的光响应性聚（苄基酯）树状聚合物的设计和合成。

  摘要：

  使用受保护的正交AB（2）单体（10）和四官能化核（11）作为构建模块，通过收敛方法设计并合成了一类新型的含有全部偶氮苯单元（最多29个偶氮苯基）的树枝状和树枝状聚合物。 。关键单体（10）的制备涉及保护的亚硝基化合物（9）和5-氨基间苯二甲酸的缩合。这些是具有全偶氮苯重复单元的光敏树状聚合物的第一个例子。[结构：见文字]

  DOI：

  10.1021/ol0165591

文献信息

• Synthesis of polyfunctional secondary amines by the addition of functionalized zinc reagents to nitrosoarenes
  作者：Vasudevan Dhayalan、Christoph Sämann、Paul Knochel

  DOI：10.1039/c4cc08846h

  日期：——

  Addition of functionalized aryl, heteroaryl or adamantyl zinc reagents to various nitroso-arenes in the presence of magnesium salts and LiCl in THF produces after a reductive work-up with FeCl2 and NaBH4 in ethanol the corresponding polyfunctional secondary amines in high yields.

  在乙醇中用FeCl2和NaBH4还原处理后，在乙醇中镁盐和LiCl的存在下，将官能化的芳基，杂芳基或金刚烷基锌试剂添加到各种亚硝基芳烃中，可以高收率得到相应的多官能仲胺。
• 偶氮芳基脲类衍生物及其制备方法和应用
  申请人：华东理工大学

  公开号：CN111217722A

  公开（公告）日：2020-06-02

  本发明涉及一种偶氮芳基脲衍生物及其制备与应用。具体地，本发明公开了具有式(I)化合物或其光学异构体、顺反异构体或药学上可接受的盐，及其制备方法，通式中各取代基的定义如说明书和权利要求书所述。本发明还公开了包含上述化合物的组合物及其用途。本发明化合物对HepG2肝癌细胞、MGC803胃癌细胞、HCT116结肠癌等具有优异的抗癌活性。
• Tailoring Surface-Confined Nanopores with Photoresponsive Groups
  作者：Kazukuni Tahara、Koji Inukai、Jinne Adisoejoso、Hiroyuki Yamaga、Tatyana Balandina、Matthew O. Blunt、Steven De Feyter、Yoshito Tobe

  DOI：10.1002/anie.201303745

  日期：2013.8.5

  Opening light: Two‐dimensional pores are formed by the self‐assembly of azobenzene‐functionalized triangular building blocks on graphite at the liquid–solid interface. These pores can selectively host a guest molecule. The pore size can be reversibly changed by irradiation at different wavelength which changes the number of guest molecules that are adsorbed (see scheme).

  开光：在液-固界面处，由偶氮苯官能化的三角形构建基块在石墨上的自组装形成了二维孔。这些孔可以选择性地容纳客体分子。孔径可以通过不同波长的辐射可逆地改变，从而改变了被吸附的客体分子的数量（参见方案）。
• NOVEL BENZODIAZEPINE DERIVATIVES
  申请人：Immunogen, Inc.

  公开号：EP3100745A1

  公开（公告）日：2016-12-07

  The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  本发明涉及具有抗增殖活性的新型苯并二氮杂卓衍生物，更具体地说，涉及式(I)和(II)的新型苯并二氮杂卓，其中二氮杂卓环(B)与杂环(CD)融合，其中杂环为双环；或式(III)的化合物，其中二氮杂卓环(B)与杂环(C)融合，其中杂环为单环。本发明提供了这些化合物的细胞毒性二聚体。本发明还提供了单体和二聚体的共轭物。本发明进一步提供了使用本发明化合物或共轭物抑制哺乳动物异常细胞生长或治疗增殖性疾病的组合物和方法。本发明进一步涉及使用本发明化合物或共轭物体外、原位和体内诊断或治疗哺乳动物细胞或相关病理状况的方法。
• Design, Synthesis, and Photochemical Behavior of Poly(benzyl ester) Dendrimers with Azobenzene Groups throughout Their Architecture
  作者：Shuangxi Wang、Ximeng Wang、Lijuan Li、Rigoberto C. Advincula

  DOI：10.1021/jo0499773

  日期：2004.12.1

  A new class of dendrons and dendrimers containing azobenzene units (bearing up to 29 azobenzene groups for four generations) were designed and synthesized with the convergent method, which uses azobenzene derivatives as monomers and benzyl ester groups as linkages leading to photoresponsive dendrons and dendrimers with azobenzene units throughout their architecture. Photochemical isomerization experiments revealed that all of the dendrons and dendrimers undergo trans-cis isomerization by irradiation and cis-trans isomerization by either irradiation or heating.