A method of covalently attaching a pre-existing nucleic acid to a metal surface or a metal cluster is disclosed. The method comprises chemically modifying the pre-existing nucleic acid, so as to obtain a functionallized pre-existing nucleic acid having a side chain terminating with a functional group, which side chain is covalently linked to a purine or pyrimidine base of the pre-existing nucleic acid, and covalently attaching the functionallized pre-existing nucleic acid to a metal surface or a metal cluster, via the functional groups. A method of preparing a thin and flat gold film is further disclosed.
                            本发明公开了一种将已有核酸共价连接到
金属表面或
金属簇上的方法。该方法包括对原有核酸进行
化学修饰,以获得功能化的原有核酸,该核酸具有以功能基团终止的侧链,该侧链与原有核酸的
嘌呤或
嘧啶碱基共价连接,并通过功能基团将功能化的原有核酸共价连接到
金属表面或
金属簇上。进一步公开了一种制备薄而平整的
金膜的方法。