2-methyl-5-[(phenylmethyl)oxy]pyrimidine | 1030379-84-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-5-[(phenylmethyl)oxy]pyrimidine
• 英文别名: 5-(Benzyloxy)-2-methylpyrimidine；2-methyl-5-phenylmethoxypyrimidine
• CAS: 1030379-84-0
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: CNHFWVASMVDEQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

文献信息

• Novel Compounds
  申请人：Chapman David

  公开号：US20080221139A1

  公开（公告）日：2008-09-11

  The invention provides compounds of formula (I): wherein R 1 and R 2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.

  本发明提供了式(I)的化合物：其中R1和R2如规范所定义；它们的制备过程；含有它们的制药组合物；制备制药组合物的过程；以及它们在治疗中的应用。这些化合物可用作MMP抑制剂。
• NOVEL PYRROLOPYRIMIDINE COMPOUND OR SALT THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING SAME, ESPECIALLY AGENT FOR PREVENTION AND/OR TREATMENT OF TUMORS ETC BASED ON NAE INHIBITORY EFFECT
  申请人：Taiho Pharmaceutical Co., Ltd.

  公开号：EP3103802A1

  公开（公告）日：2016-12-14

  An object to be solved by the present invention is to provide a novel pyrrolopyrimidine compound or a salt thereof having an NAE inhibitory action and a cell growth inhibitory effect. The present invention provides a compound or a salt thereof represented by Formula (A), as well as an NAE inhibitor, a pharmaceutical composition, and an antitumor agent comprising the compound or a salt thereof as an active ingredient.

  本发明要解决的一个问题是提供一种新型吡咯并嘧啶化合物或其盐，该化合物或其盐具有NAE抑制作用和细胞生长抑制作用。本发明提供了一种由式（A）表示的化合物或其盐，以及一种 NAE 抑制剂、一种药物组合物和一种包含该化合物或其盐作为活性成分的抗肿瘤剂。
• Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US10174040B2

  公开（公告）日：2019-01-08

  A pyrrolopyrimidine compound or a salt thereof and compositions, NAE inhibitors and anti-tumor agents containing the pyrrolopyrimidine compound or a salt thereof. The pyrrolopyrimidine compound or a salt thereof has an NAE inhibitory action and a cell growth inhibitory effect and is represented by Formula (A):

  一种吡咯并嘧啶化合物或其盐，以及含有该吡咯并嘧啶化合物或其盐的组合物、NAE 抑制剂和抗肿瘤剂。该吡咯并嘧啶化合物或其盐具有 NAE 抑制作用和细胞生长抑制作用，由式（A）表示：
• HYDANTOIN DERIVATIVES USED AS MMP INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP2097406B1

  公开（公告）日：2011-07-20
• PYRROLOPYRIMIDINE COMPOUND OR SALT THEREOF AND COMPOSITIONS CONTAINING THE PYRROLOPYRIMIDINE COMPOUND OR SALT THEREOF
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：US20180162864A1

  公开（公告）日：2018-06-14

  A pyrrolopyrimidine compound or a salt thereof and compositions, NAE inhibitors and anti-tumor agents containing the pyrrolopyrimidine compound or a salt thereof. The pyrrolopyrimidine compound or a salt thereof has an NAE inhibitory action and a cell growth inhibitory effect and is represented by Formula (A):