5-phenylpentyl (methyl 3-O-methyl-4-O-tert-butyldiphenylsilyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside | 1388151-06-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-phenylpentyl (methyl 3-O-methyl-4-O-tert-butyldiphenylsilyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside
• CAS: 1388151-06-1
• 化学式: C₁₃₅H₁₉₈O₄₅Si₃
• 分子量: 2625.29
• InChiKey: ZOQBUPQYXVQYBN-NVWHVHBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.99
• 重原子数：
  183.0
• 可旋转键数：
  65.0
• 环数：
  15.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  512.71
• 氢给体数：
  6.0
• 氢受体数：
  45.0

反应信息

• 作为反应物：
  描述：

  5-phenylpentyl (methyl 3-O-methyl-4-O-tert-butyldiphenylsilyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside 、 三氧化硫-三乙胺复合物 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 5-phenylpentyl (methyl 3-O-methyl-4-O-tert-butyldiphenylsilyl-2-O-triethylammonium sulphonato-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-triethylammonium sulphonato-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-2-O-triethylammonium sulphonato-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-triethylammonium sulphonato-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-2-O-triethylammonium sulphonato-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-2-O-triethylammonium sulphonato-α-L-idopyranosyluronate)-(1->4)-2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside
  参考文献：
  名称：

  [EN] FGF RECEPTOR-ACTIVATING 3-O-ALKYL OLIGOSACCHARIDES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  [FR] 3-O-ALKYL-OLIGOSACCHARIDES ACTIVATEURS DE RÉCEPTEUR FGF, PRÉPARATION DE CEUX-CI ET UTILISATION THÉRAPEUTIQUE DE CEUX-CI

  摘要：

  该发明涉及与式（I）中R1代表可选择地取代的-O-烷基基团，R2代表羟基或-O-烷基基团，R3、R5、R6、R7和R8代表-OSO3-或羟基，R4代表NH-CO-烷基或-O-烷基基团，R代表-O-烷基基团，n和m，可以相同也可以不同，代表整数0或1的FGF受体激活寡糖。其制备方法和治疗用途。

  公开号：

  WO2012101605A1
• 作为产物：
  描述：

  5-phenylpentyl (methyl 2-O-benzoyl-3-O-methyl-4-O-tert-butyldiphenylsilyl-α-L-idopyranosyluronate)-(1->4)-(6-O-acetyl-2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 2-O-benzoyl-3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(6-O-acetyl-2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 2-O-benzoyl-3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-α-D-glucopyranosyl)-(1->4)-(methyl 2-O-benzoyl-3-O-methyl-α-L-idopyranosyluronate)-(1->4)-2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside 在 potassium tert-butylate 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 125.0h， 生成 5-phenylpentyl (methyl 3-O-methyl-4-O-tert-butyldiphenylsilyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-(2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-α-D-glucopyranosyl)-(1->4)-(methyl 3-O-methyl-α-L-idopyranosyluronate)-(1->4)-2-O-butyl-3-O-methyl-6-O-tert-butyldiphenylsilyl-β-D-glucopyranoside
  参考文献：
  名称：

  [EN] FGF RECEPTOR-ACTIVATING 3-O-ALKYL OLIGOSACCHARIDES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  [FR] 3-O-ALKYL-OLIGOSACCHARIDES ACTIVATEURS DE RÉCEPTEUR FGF, PRÉPARATION DE CEUX-CI ET UTILISATION THÉRAPEUTIQUE DE CEUX-CI

  摘要：

  该发明涉及与式（I）中R1代表可选择地取代的-O-烷基基团，R2代表羟基或-O-烷基基团，R3、R5、R6、R7和R8代表-OSO3-或羟基，R4代表NH-CO-烷基或-O-烷基基团，R代表-O-烷基基团，n和m，可以相同也可以不同，代表整数0或1的FGF受体激活寡糖。其制备方法和治疗用途。

  公开号：

  WO2012101605A1