2-(4-methoxyphenyl)-4H-pyrazolo[1,5-a]benzimidazole | 1185994-39-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-methoxyphenyl)-4H-pyrazolo[1,5-a]benzimidazole
• CAS: 1185994-39-1
• 化学式: C₁₆H₁₃N₃O
• 分子量: 263.299
• InChiKey: MRYWYPBKYDKTMZ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  5(3)-(2-bromoanilino)-3(5)-(4-methoxyphenyl)-1H-pyrazole 在 copper(l) iodide 、 sodium hydride 、 L-脯氨酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以84%的产率得到2-(4-methoxyphenyl)-4H-pyrazolo[1,5-a]benzimidazole
  参考文献：
  名称：

  Efficient Routes to Pyrazolo[3,4-b]indoles and Pyrazolo[1,5-a]benzimidazoles via Palladium- and Copper-Catalyzed Intramolecular C−C and C−N Bond Formation

  摘要：

  Efficient synthetic routes to pyrazolo[3,4-b]indoles and pyrazolo[1,5-a]benzimidazoles via intramolecular palladium- and copper-catalyzed cyclization of 1-aryl/1-unsubstituted 5-(2-bromoanilino)-pyrazole precursors via intramolecular C-C and C-N bond formation have been reported.

  DOI：

  10.1021/jo901309t

文献信息

• Synthesis of N-unsubstituted 2-arylpyrazolo[1,5-a]benzimidazoles from 1-benzylideneamino-2-methylbenzimidazole and the role of acylotropic and acylotropic-prototropic isomerization
  作者：T. A. Kuz’menko、L. N. Divaeva、A. S. Morkovnik

  DOI：10.1007/s11172-011-0085-z

  日期：2011.3

  Abstract2-Aryl-4H-pyrazolo[1,5-a]benzimidazoles were synthesized for the first time from 1-benzyl-ideneamino-2-methylbenzimidazole by the benzoylation of the methyl group followed by the cyclization of the resulting vinyl acylates in concentrated HCl. The key steps of the process were studied by quantum chemical methods for model systems. It was shown that the concerted intramolecular acylotropic and

  摘要 2-芳基-4H-吡唑并[1,5-a]苯并咪唑首次由1-苄基-亚氨基-2-甲基苯并咪唑通过甲基的苯甲酰化，然后在浓HCl中环化所得的乙烯基酰化物而合成。 . 通过模型系统的量子化学方法研究了该过程的关键步骤。结果表明，协同的分子内旋致和旋致-质子转变在该过程中起着重要作用。