2-Ethyl-3-<2-methoxy-benzoyl>-benzofuran | 65246-22-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Ethyl-3-<2-methoxy-benzoyl>-benzofuran
• 英文别名: (2-ethyl-benzofuran-3-yl)-(2-methoxy-phenyl)-methanone；2-ethyl-3-(o-anisoyl)benzofuran；(2-ethyl-1-benzofuran-3-yl)-(2-methoxyphenyl)methanone
• CAS: 65246-22-2
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: DLKGVLCJWCUTPZ-UHFFFAOYSA-N

物化性质

• 熔点：
  64 °C
• 沸点：
  453.3±40.0 °C(Predicted)
• 密度：
  1.161±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Ethyl-3-<2-methoxy-benzoyl>-benzofuran 生成 (2-Ethyl-1-benzofuran-3-yl)-(2-hydroxyphenyl)methanone
  参考文献：
  名称：

  TOMIYAMA, TSUYOSHI;TOMIYAMA, AKIRA;KUBOTA, KOICHI

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙基苯并呋喃 以87%的产率得到
  参考文献：
  名称：

  ASTOIN J.; DEMERSEMAN P.; PLATZER N.; ROYER R., J. HETEROCYCL. CHEM. , 1977, 14, NO 5, 861-866

  摘要：

  DOI：

文献信息

• Benzothiophene derivatives and antihyperuricemia thereof
  申请人：Kotobuki Seiyaku Company Limited

  公开号：US05175184A1

  公开（公告）日：1992-12-29

  A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic adic derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

  本发明揭示了一系列苯并呋喃和苯并噻吩衍生物。这些化合物具有一种结构，可以通过用取代苯衍生物、顺丁烯二酸衍生物或取代苯氧甲基四唑衍生物替换2-较低烷基苯并呋喃或2-较低烷基苯并噻吩的第三位置得到。它们可用作利尿剂，而不会引起血清尿酸水平升高的副作用，并可用于治疗高尿酸血症。
• Benzofuran and benzothoiphene derivatives, of tetrazole and
  申请人：Kotobuki Seiyaku Company Limited

  公开号：US05004750A1

  公开（公告）日：1991-04-02

  A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic acid derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

  本发明公开了一种新系列的苯并呋喃和苯并噻吩衍生物。这些化合物的结构可以通过用取代苯基衍生物、顺丁烯二酸衍生物或取代苯氧甲基四唑衍生物取代2-较低烷基苯并呋喃或2-较低烷基苯并噻吩的第三个位置而得到。它们可用作利尿剂，而不会产生升高血清尿酸水平的副作用，并可用于治疗高尿酸血症。
• Benzofuran and benzothiophene derivatives, anti-hyperuricemia agents
  申请人：Kotobuki Seiyaku Company Limited

  公开号：US05274000A1

  公开（公告）日：1993-12-28

  A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic acid derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

  本发明涉及一种新的苯并呋喃和苯并噻吩衍生物系列，这些化合物的结构可通过将2-较低烷基苯并呋喃或2-较低烷基苯并噻吩的第三位置替换为取代苯衍生物、顺丁烯二酸衍生物或取代苯氧甲基四唑衍生物来获得。它们可用作利尿剂，不会引起血清尿酸水平升高的副作用，并可用于治疗高尿酸血症。
• Benzofuran derivatives and use thereof for treating hyperuricemia
  申请人：Kotobuki Seiyaku Company Limited

  公开号：US04797415A1

  公开（公告）日：1989-01-10

  A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or 2-lower alkyl-benzothiophene with a substituted benzene derivative, itaconic acid derivative or a substituted phenoxymethyl tetrazole derivative. They are useful as diuretics without side effects of elevating serum uric acid levels and can be used in the treatment of hyperuricemia.

  公开了一种新的苯并呋喃和苯并噻吩衍生物系列。这些化合物的结构可以通过将2-较低烷基苯并呋喃或2-较低烷基苯并噻吩的第三位用取代苯衍生物、曲酸衍生物或取代苯氧甲基四唑衍生物进行取代而获得。它们可用作利尿剂，而不会引起升高血清尿酸水平的副作用，并可用于治疗高尿酸血症。
• TOMIYAMA, TSUYOSHI;TOMIYAMA, AKIRA;KUBOTA, KOICHI
  作者：TOMIYAMA, TSUYOSHI、TOMIYAMA, AKIRA、KUBOTA, KOICHI

  DOI：——

  日期：——