1-Amino-1-desoxy-D-idit | 842147-52-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Amino-1-desoxy-D-idit
• 英文别名: (2R,3S,4S,5R)-6-aminohexane-1,2,3,4,5-pentol
• CAS: 842147-52-8
• 化学式: C₆H₁₅NO₅
• 分子量: 181.189
• InChiKey: SDOFMBGMRVAJNF-ZXXMMSQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  127
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• [EN] INHIBITORS OF Akt ACTIVITY<br/>[FR] INHIBITEURS DE L'ACTIVITE DE AKT
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005011700A1

  公开（公告）日：2005-02-10

  Invented are novel 1 H-imidazo[4,5-c]pyridin-2-yI compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

  发明了新型的1H-咪唑[4,5-c]吡啶-2-基化合物，这些化合物用作蛋白激酶B活性的抑制剂，并用于治疗癌症和关节炎。
• [EN] CONTRAST AGENTS<br/>[FR] AGENTS DE CONTRASTE
  申请人：BRACCO IMAGING SPA

  公开号：WO2017098038A1

  公开（公告）日：2017-06-15

  The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5

  本发明涉及一类新型的功能化大环化合物，能够螯合顺磁性金属离子，以及它们与金属离子形成的螯合络合物，以及将其用作对比剂的用途，特别适用于磁共振成像（MRI）分析。
• Inhibitors of Akt Activity
  申请人：Heerding Dirk A.

  公开号：US20080255143A1

  公开（公告）日：2008-10-16

  Invented are novel 1H-imidazo[4,5-c]pyridin-2-yl compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

  发明了新型的1H-咪唑[4,5-c]吡啶-2-基化合物，这些化合物可用作蛋白激酶B活性抑制剂，并用于癌症和关节炎的治疗。
• FILLER FOR LIQUID CHROMATOGRAPHY AND LIQUID CHROMATOGRAPHY COLUMN
  申请人：Showa Denko K.K.

  公开号：EP3112858A1

  公开（公告）日：2017-01-04

  Apackingmaterial for liquidchromatography, which is excellent in durability, and a column for liquid chromatography, which is filled with the packing material, are provided. The packing material for liquid chromatography is characterized by comprising a hydrophilic resin containing a polyvinyl alcohol resin, to said hydrophilic resin an amino group represented by the formula (1) having been bonded through a spacer. In the formula (1), R1 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R2 represents an alkyl group having 1 to 6 carbon atoms and having one or more hydroxyl groups, and represents a bonding position to the spacer.

  本发明提供了一种耐久性极佳的液相色谱用填料和一种填充了该填料的液相色谱柱。液相色谱用填料的特点是由含有聚乙烯醇树脂的亲水性树脂组成，在所述亲水性树脂上通过间隔键连接有由式（1）表示的氨基。在式 (1) 中，R1 代表氢原子或具有 1 至 4 个碳原子的烷基，R2 代表具有 1 至 6 个碳原子且具有一个或多个羟基的烷基，并代表与间隔物的键合位置。
• LIQUID CHROMATOGRAPHY COLUMN AND LIQUID CHROMATOGRAPHY DEVICE EQUIPPED WITH SAME
  申请人：Showa Denko K.K.

  公开号：EP3346266A1

  公开（公告）日：2018-07-11

  A liquid chromatographic column includes: a cylindrical column body; an inflow-side filter that is disposed at an eluent inflow-side end of the column body; an outflow-side filter that is disposed at an eluent outflow-side end of the column body; and a filler that is filled between the inflow-side filter and the outflow-side filter, in which the inflow-side filter has a two-layer structure consisting of a first resin filter member and a second resin filter member which are disposed in this order from a side of the filler, and the first resin filter member has an indentation elastic modulus lower than that of the second resin filter member.

  液相色谱柱包括圆柱形柱体； 设置在柱体洗脱液流入侧一端的流入侧过滤器； 设置在柱体洗脱液流出侧一端的流出侧过滤器；以及填充在流入侧过滤器和流出侧过滤器之间的填料，其中流入侧过滤器具有由第一树脂过滤件和第二树脂过滤件组成的双层结构，第一树脂过滤件从填料的一侧依次布置，第一树脂过滤件的压痕弹性模量低于第二树脂过滤件的压痕弹性模量。