1,5-Dioxocan | 6572-92-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,5-Dioxocan
• 英文别名: [1,5]dioxocane；1,5-Dioxocane
• CAS: 6572-92-5
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: AKABANAMZRMCCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME<br/>[FR] INHIBITEURS DE DCN1 À PETITES MOLÉCULES ET PROCÉDÉS THÉRAPEUTIQUES LES UTILISANT
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2018183411A1

  公开（公告）日：2018-10-04

  Compounds of formula (I) as inhibitors of DCNl and compositions containing the same are disclosed. Methods of using the DCNl inhibitors in the treatment of diseases and conditions wherein inhibition of DCNl provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.

  公式（I）的化合物被披露为DCNl的抑制剂，以及含有这些化合物的组合物。还披露了在治疗疾病和病况中使用DCNl抑制剂的方法，其中DCNl的抑制提供益处，如氧化应激相关的疾病和病况、神经退行性疾病和病况、代谢紊乱以及肌肉神经退化。
• Covalent Small Molecule DCN1 Inhibitors and Therapeutic Methods Using the Same
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20180289677A1

  公开（公告）日：2018-10-11

  Small molecule covalent inhibitors of DCN1 and compositions containing the same are disclosed. Methods of using the DCN1 covalent inhibitors in the treatment of diseases and conditions wherein inhibition of DCN1 provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.

  揭示了DCN1的小分子共价抑制剂和含有这些抑制剂的组合物。还揭示了在治疗疾病和状况中使用DCN1共价抑制剂的方法，其中DCN1的抑制提供益处，如氧化应激相关的疾病和状况、神经退行性疾病和状况、代谢紊乱以及肌肉神经退化。
• [EN] QUINAZOLIN-4(3H)-ONE-TYPE PIPERIDINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE PIPÉRIDINE DU TYPE QUINAZOLIN-4(3H)-ONE ET UTILISATIONS DE CEUX-CI
  申请人：PURDUE PHARMA LP

  公开号：WO2014102589A1

  公开（公告）日：2014-07-03

  The present disclosure relates to Quinazolin-4(3H)-one-Type Piperidine Compounds, such as those of Formule (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Q, Y1, Z, A, B, E, and a are as defined herein; compositions comprising an effective amount of a Quinazolin-4(3H)-one-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Quinazolin-4(3 H)-one-Type Piperidine Compound.

  本公开涉及喹唑啉-4(3H)-酮型哌啶化合物，例如公式(I)中的化合物及其药学上可接受的盐和溶剂，其中R1、R2、R3、Q、Y1、Z、A、B、E和a如本文所定义；包含有效量喹唑啉-4(3H)-酮型哌啶化合物的组合物；以及治疗或预防疼痛等疾病的方法，包括向需要的动物施用有效量喹唑啉-4(3H)-酮型哌啶化合物。
• [EN] MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE<br/>[FR] MONOBACTAMES ET PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION DE CES DERNIERS
  申请人：HARVARD COLLEGE

  公开号：WO2015103583A1

  公开（公告）日：2015-07-09

  Described herein are monobactam antibiotics of Formula (I), (Ι'), (II), and (II'), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.

  本文描述了单环内酰胺抗生素的化学式(I)、(Ι')、(II)和(II')，以及制备这些化合物的方法和中间体。还提供了使用单环内酰胺治疗传染病的药物组合物和方法。
• PHOTORESIST COMPOSITION, RESIST PATTERN-FORMING METHOD, COMPOUND, ACID GENERATING AGENT, AND PHOTODEGRADABLE BASE
  申请人：JSR CORPORATION

  公开号：US20140363769A1

  公开（公告）日：2014-12-11

  A photoresist composition containing a polymer having a structural unit including an acid-labile group, and a compound represented by the formula (1). In the formula (1), R 1 represents a hydrogen atom or a monovalent acid-labile group. R 2 represents an alicyclic hydrocarbon group having 3 to 20 carbon atoms and a valency of (m+1). m is an integer of 2 to 5. R 3 and R 4 each independently represent a hydrogen atom, a fluorine atom, a monovalent hydrocarbon group having 1 to 20 carbon atoms or a monovalent fluorinated hydrocarbon group having 1 to 20 carbon atoms. n is an integer of 0 to 5. At least two of a plurality of R 1 s optionally taken together represent a ring structure, together with a plurality of oxygen atoms bonding to R 1 and the carbon atom(s) constituting R 2 and bonding to these oxygen atoms. M + represents a monovalent radiation-degradable onium cation.

  一种光刻胶组合物，包含具有酸敏感基团的结构单元的聚合物和由公式（1）表示的化合物。在公式（1）中，R1表示氢原子或一价酸敏感基团。R2表示具有3至20个碳原子和价态为（m+1）的脂环烃基团。m为2至5的整数。R3和R4分别独立地表示氢原子、氟原子、具有1至20个碳原子的一价碳氢基团或具有1至20个碳原子的一价氟碳基团。n为0至5的整数。至少两个可选的R1中的多个与与这些氧原子结合的R2所构成的碳原子形成环状结构。M+表示一价辐射降解的离子。