| 1242170-57-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1242170-57-5
• 化学式: C₃₇H₇₃N₉O₂₄S
• 分子量: 1060.1
• InChiKey: DKLFMEQKLNYXMN-ZTVXPPBPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -15.32
• 重原子数：
  71.0
• 可旋转键数：
  22.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  581.72
• 氢给体数：
  23.0
• 氢受体数：
  32.0

反应信息

• 作为产物：
  描述：

  氨基硫脲 、 hexa-chitohexaose 在 sodium cyanoborohydride 、 sodium hydroxide 作用下， 以 水 、 甲醇 为溶剂， 反应 24.0h， 以95.6%的产率得到
  参考文献：
  名称：

  Preparation and cell culture behavior of self-assembled monolayers composed of chitohexaose and chitosan hexamer

  摘要：

  Chitohexaose and chitosan hexamer were site-selectively modified at each reducing end with thiosemicarbazide, followed by self-assembly chemisorption of the S-derivatives on a gold substrate via. S-Au bonding. Quartz crystal microbalance analysis and X-ray photoelectron spectroscopy suggested successful formation of self-assembled monolayers (SAMs) consisting of chitin and chitosan with sugar densities 0.39 and 0.35 chains nm(-2), respectively. As-prepared SAMs were very hydrophilic (with water contact angles 12-13 degrees) and flat at the nanometer scale (RMS approximate to 1.7 nm). Mouse fibroblasts (NIH-3T3) preferentially adhered to both SAMs, while fewer cells were attached to the more hydrophobic, intact gold substrate. The fixed carbohydrates induced good proliferation of NIH-3T3 cells, while surface treatment with free sugars had almost no positive effects. This architectural design of water-soluble oligosaccharide-SAMs is expected to provide a new approach for functional development of carbohydrate-decorated biointerfaces. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2010.04.015