6-(Perylen-3-ylmethylamino)hexan-1-ol | 403991-04-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 6-(Perylen-3-ylmethylamino)hexan-1-ol
• CAS: 403991-04-8
• 化学式: C₂₇H₂₇NO
• 分子量: 381.517
• InChiKey: ATGNDFTTWXJOGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 6-(Perylen-3-ylmethylamino)hexan-1-ol 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到3-[[Di(propan-2-yl)amino]-[6-(perylen-3-ylmethylamino)hexoxy]phosphanyl]oxypropanenitrile
  参考文献：
  名称：

  Synthesis and binding properties of perylene-oligo-2′-deoxyribonucleotide conjugates

  摘要：

  Perylene has been covalently linked, via polymethylene tethers. to the 5'- and the 3'-ends of an oligopyrimidine sequence. The presence of the polycyclic ligand stabilizes the duplexes and the triplexes formed by the modified oligonucleotides and their single- and double-stranded DNA targets Lis compared to those formed with the parent unmodified oligonucleotide used as reference. Stabilization of the triplex is at its highest when perylene is linked to the 5'-end of the oligonucleotide via a nine-atom size linker. Stabilization of the duplexes is nearly equivalent whatever the position of the substitution (5' or 3') and the linker size used to tether both entities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02010-x
• 作为产物：
  描述：

  苝 在 四氯化锡 、 对甲苯磺酸 作用下， 以 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 36.0h， 生成 6-(Perylen-3-ylmethylamino)hexan-1-ol
  参考文献：
  名称：

  Synthesis and binding properties of perylene-oligo-2′-deoxyribonucleotide conjugates

  摘要：

  Perylene has been covalently linked, via polymethylene tethers. to the 5'- and the 3'-ends of an oligopyrimidine sequence. The presence of the polycyclic ligand stabilizes the duplexes and the triplexes formed by the modified oligonucleotides and their single- and double-stranded DNA targets Lis compared to those formed with the parent unmodified oligonucleotide used as reference. Stabilization of the triplex is at its highest when perylene is linked to the 5'-end of the oligonucleotide via a nine-atom size linker. Stabilization of the duplexes is nearly equivalent whatever the position of the substitution (5' or 3') and the linker size used to tether both entities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02010-x