methyl 4-[4-(phenylmethoxycarbonylamino)butanoylamino]butanoate | 90139-76-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: methyl 4-[4-(phenylmethoxycarbonylamino)butanoylamino]butanoate
• CAS: 90139-76-7
• 化学式: C₁₇H₂₄N₂O₅
• 分子量: 336.388
• InChiKey: CPKMDLLUBUIJMH-UHFFFAOYSA-N

物化性质

• 沸点：
  560.2±45.0 °C(Predicted)
• 密度：
  1.149±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.76
• 重原子数：
  24.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  93.73
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  methyl 4-[4-(phenylmethoxycarbonylamino)butanoylamino]butanoate 在 sodium hydroxide 、 erythritol tetranitrate 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 32.0h， 生成 methyl 3,8,13-trioxo-1-phenyl-2-oxa-4,9,14-triazaoctadecan-18-oate
  参考文献：
  名称：

  Ligands for expression cloning and isolation of GABAB receptors

  摘要：

  The scope of the plenary lecture at the occasion of the Xth Meeting on Heterocyclic Structures in Medicinal Chemistry, Palermo 2002, is considerably larger than that of the main lecture at the XVIth International Symposium on Medicinal Chemistry, Bologna 2000, described by Froestl et al. in Farmaco 56 (2001) 101. Additional information is presented, in particular, on the reaction conditions for the 31 step synthesis of the combined affinity chromatography and photoaffinity radioligand [125I]CGP84963 and on the recent developments of the molecular biology of GABA(B) receptors.

  DOI：

  10.1016/s0014-827x(03)00018-1
• 作为产物：
  描述：

  N-苄氧羰基-4-氨基丁酸 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.83h， 生成 methyl 4-[4-(phenylmethoxycarbonylamino)butanoylamino]butanoate
  参考文献：
  名称：

  Methotrexate analogs. 29. Effect of .gamma.-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition

  摘要：

  A series of "stretched" methotrexate (MTX) analogues containing up to five 4-aminobutyryl (Gab) spacers between the 4-amino-4-deoxy-N10-methylpteroyl (MeAPA) moiety and the glutamate (Glu) side chain was prepared. Interest in these compounds stemmed from their relationship to MTX gamma-polyglutamates, from which they differ only in lacking "internal" alpha-carboxyl groups. The ability of the MeAPA-Gabn-Glu derivatives to inhibit dihydrofolate reductase (DHFR) and thymidylate synthase (TS) in vitro and to inhibit the growth of tumor cells in culture was evaluated. The IC50 for DHFR inhibition increased progressively from 0.082 to 0.84 microM as the number of Gab spacers was varied from one to five. At the same time the introduction of Gab spacers was found to produce substantial TS inhibition (Ki 0.1-0.4 microM) similar to that reported for MTX polyglutamates. Despite the activity of the MeAPA-Gabn-Glu derivatives as combined inhibitors of TS and DHFR, there was a steep loss of cell growth inhibitory potency as the number of Gab spacers was increased. This most likely reflects low cell uptake and the fact that when n greater than 1 there is almost total abolition of substrate activity for folylpolyglutamate synthetase, which had previously been observed with n = 1.

  DOI：

  10.1021/jm00160a014