2-Methyl-4-propionyl-thiophen | 106265-83-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-4-propionyl-thiophen
• 英文别名: 1-(5-methyl-thiophen-3-yl)-propan-1-one；1-(5-Methylthiophen-3-yl)propan-1-one
• CAS: 106265-83-2
• 化学式: C₈H₁₀OS
• 分子量: 154.233
• InChiKey: VFYHSYIWXOABCB-UHFFFAOYSA-N

物化性质

• 沸点：
  232.9±20.0 °C(Predicted)
• 密度：
  1.076±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methyl-4-propionyl-thiophen 以27%的产率得到
  参考文献：
  名称：

  FREJD T.; KARLSSON O., TETRAHEDRON, 1979, 35, NO 18, 2155-2159

  摘要：

  DOI：

文献信息

• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20150057309A1

  公开（公告）日：2015-02-26

  The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.

  本发明提供了作为c-Met蛋白激酶调节剂有用的化合物，以及制备它们的方法，含有它们的药物组合物，以及使用它们进行治疗、预防和/或改善c-Met激酶介导的疾病或疾病的方法。
• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：MUTHUPPALANIAPPAN Meyyappan

  公开号：US20110281865A1

  公开（公告）日：2011-11-17

  The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了一种公式I的化合物作为蛋白激酶调节剂，以及它们的制备方法、含有它们的药物组合物，以及利用它们治疗、预防和/或改善激酶介导的疾病或紊乱的方法。
• NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES
  申请人：Rhizen Pharmaceuticals SA

  公开号：US20130261116A1

  公开（公告）日：2013-10-03

  The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

  本发明提供了一些公式I化合物作为蛋白激酶调节剂，它们的制备方法，包含它们的制药组合物，以及使用它们进行激酶介导的疾病或障碍的治疗、预防和/或改善的方法。
• ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：US20130196978A1

  公开（公告）日：2013-08-01

  Alkaloid aminoester compounds which act as muscarinic receptor antagonists are useful for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.

  生物碱氨酯化合物，其作为毒蕈碱受体拮抗剂，对于预防和/或治疗支气管阻塞性或炎症性疾病是有用的。
• Thiophene ring-substituted alpha-(alkylaminopropionyl)-thiophene derivatives, a process for preparing them and pharmaceutical compositions containing them
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP0196001A1

  公开（公告）日：1986-10-01

  The invention relates to thiophene ring-substituted a-(al- kylaminopropionyl)-thiophene derivatives having the general formula (I): wherein X is methyl or chlorine, R is alkyl, linear or branched, having 3 to 4 carbon atoms, and the nontoxic addition salts thereof, as well as to a process for preparing these compounds and to pharmaceutical compositions containing these compounds. These compounds are useful for treating depressions.

  本发明涉及具有通式(I)的噻吩环取代a-(al-kylaminopropionyl)-噻吩衍生物：其中X为甲基或氯，R为具有3至4个碳原子的直链或支链烷基，及其无毒加成盐，以及制备这些化合物的工艺和含有这些化合物的药物组合物。 这些化合物可用于治疗抑郁症。