5-(3,3,6-trimethyl-1,3-dihydro-isobenzofuran-5-yloxy)-furan-2-carboxylic acid N'-(5-trifluoromethyl-pyridin-2-yl)-hydrazide | 637013-60-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(3,3,6-trimethyl-1,3-dihydro-isobenzofuran-5-yloxy)-furan-2-carboxylic acid N'-(5-trifluoromethyl-pyridin-2-yl)-hydrazide
• 英文别名: N'-[5-(trifluoromethyl)pyridin-2-yl]-5-[(3,3,6-trimethyl-1H-2-benzofuran-5-yl)oxy]furan-2-carbohydrazide
• CAS: 637013-60-6
• 化学式: C₂₂H₂₀F₃N₃O₄
• 分子量: 447.414
• InChiKey: NTEOCMMGZTWFQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  85.6
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE<br/>[FR] AGENTS ANTI-GNRH NON PEPTIDIQUES, COMPOSITIONS PHARMACEUTIQUES ET PROCEDES D'UTILISATION
  申请人：PFIZER

  公开号：WO2003106446A1

  公开（公告）日：2003-12-24

  Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression o£ gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

  描述了能够抑制促性腺激素释放激素作用的非肽类GnRH药物。这些化合物及其药用可接受的盐类、前药和活性代谢物适用于治疗哺乳动物的生殖障碍和类固醇激素依赖性肿瘤，以及调节生育能力，其中表明需要抑制促性腺激素释放。还描述了合成这些化合物和在其制备中有用的中间体的方法。
• Non-peptide GnRH agents, pharmaceutical compositions and methods for their use
  申请人：Agouron Pharmaceuticals, Inc.

  公开号：US20040014787A1

  公开（公告）日：2004-01-22

  Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

  本文描述了能够抑制促性腺激素释放激素作用的非肽类GnRH（促性腺激素释放激素）药物。这些化合物及其药学上可接受的盐、前药和活性代谢物适用于治疗哺乳动物生殖障碍和类固醇激素依赖性肿瘤，以及调节生育，其中需要抑制促性腺激素释放。本文还描述了合成这些化合物和其制备中有用的中间体的方法。
• NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE
  申请人：PFIZER INC.

  公开号：EP1560818A1

  公开（公告）日：2005-08-10
• US6903132B2
  申请人：——

  公开号：US6903132B2

  公开（公告）日：2005-06-07