(4Z)-2-phenyl-4-(2-sulfanylphenyl)imino-chromen-3-ol | 1361237-34-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (4Z)-2-phenyl-4-(2-sulfanylphenyl)imino-chromen-3-ol
• 英文别名: 2-phenyl-4-(2-sulfanylphenyl)iminochromen-3-ol
• CAS: 1361237-34-4
• 化学式: C₂₁H₁₅NO₂S
• 分子量: 345.422
• InChiKey: FHTRIUCJPANQRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-羟基黄酮 、 2-氨基苯硫醇 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以68%的产率得到(4Z)-2-phenyl-4-(2-sulfanylphenyl)imino-chromen-3-ol
  参考文献：
  名称：

  Novel metal based anti-tuberculosis agent: Synthesis, characterization, catalytic and pharmacological activities of copper complexes

  摘要：

  Copper complexes of molecular formulae, [CuL1(OAc)], [CuL2(H2O)], [CuL3(H2O)], [CuL4(H2O)], [CuL5(H2O)] where L-1-L-5 represents Schiff base ligands by the condensation of 3-hydroxyflavone with 4-aminoantipyrine (L-1)/o-aminophenol (L-2)/o-aminobenzoic acid (L-3)/o-aminothiazole (L-4)/thio-semicarbazide (L-5)], have been prepared. They were characterized using analytical and spectral techniques. The DNA binding properties of copper complexes were studied using electronic absorption spectra and viscosity measurements. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. Furthermore, the copper complexes have been found to promote pUC18 DNA cleavage in the presence of oxidant. Anti-tuberculosis activity was also performed. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.01.006

文献信息

• Novel metal based anti-tuberculosis agent: Synthesis, characterization, catalytic and pharmacological activities of copper complexes
  作者：J. Joseph、K. Nagashri、G. Boomadevi Janaki

  DOI：10.1016/j.ejmech.2012.01.006

  日期：2012.3

  Copper complexes of molecular formulae, [CuL1(OAc)], [CuL2(H2O)], [CuL3(H2O)], [CuL4(H2O)], [CuL5(H2O)] where L-1-L-5 represents Schiff base ligands by the condensation of 3-hydroxyflavone with 4-aminoantipyrine (L-1)/o-aminophenol (L-2)/o-aminobenzoic acid (L-3)/o-aminothiazole (L-4)/thio-semicarbazide (L-5)], have been prepared. They were characterized using analytical and spectral techniques. The DNA binding properties of copper complexes were studied using electronic absorption spectra and viscosity measurements. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. Furthermore, the copper complexes have been found to promote pUC18 DNA cleavage in the presence of oxidant. Anti-tuberculosis activity was also performed. (C) 2012 Elsevier Masson SAS. All rights reserved.