| 1335144-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1335144-85-8
• 化学式: C₁₅H₁₀ClN₃O
• 分子量: 283.717
• InChiKey: GXIJEGMQSZQERS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.29
• 重原子数：
  20.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.78
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  对氯苯胺 在 盐酸 、 sodium azide 作用下， 以 乙醚 、 水 为溶剂， 反应 75.0h， 生成
  参考文献：
  名称：

  Synthesis, antimicrobial and antimycobacterial evaluation of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones

  摘要：

  A series of [2-(substituted phenyl)-imidazol-1-yl]-pyridin-3-yl-methanones (1-11) were synthesized and screened for their antimicrobial and antimycobacterial activities. Further, a series of [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones (12-20) reported in our earlier study was also screened for their antimycobacterial activity. The antimycobacterial activity results indicated that [2-(4-Nitro-phenyl)-imidazol-1-yl]-pyridin-3-yl-methanone (8, minimum inhibitory concentration [MIC] = 3.13 mu g) was equipotent as standard drug ciprofloxacin and [2-(4-Nitrophenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanone (16, MIC = 1.56 mu g) was equipotent as standard drug ethambutol. The results of antimicrobial screening demonstrated that 2-[1-(Pyridine-3-carbonyl)-1H-imidazol-2-yl]-benzoic acid (compound 11, MIC = 0.002 mu g) was two times more effective than standard drug ciprofloxacin (MIC = 0.004 mu g) against tested bacterial strains and [2-(2,5-Dimethyl-phenyl)-imidazol-1-yl]-pyridin-3-yl-methanone (compound 3, MIC = 0.005 mu g) was equipotent to the reference compound, fluconazole against tested fungal strains.

  DOI：

  10.3109/14756366.2010.548331