ethyl 5-(o-hydroxybenzoyl)-1-(2'-sec-butylphenyl)pyridin-2(1H)-one-3-carboxylate | 1432594-97-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 5-(o-hydroxybenzoyl)-1-(2'-sec-butylphenyl)pyridin-2(1H)-one-3-carboxylate
• CAS: 1432594-97-2
• 化学式: C₂₅H₂₅NO₅
• 分子量: 419.477
• InChiKey: FJBCUVFZINYUAR-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  、 2-(1-甲丙基)苯胺 在 cesium fluoride 作用下， 以 二氯甲烷 为溶剂， 反应 27.0h， 生成 ethyl 5-(o-hydroxybenzoyl)-1-(2'-sec-butylphenyl)pyridin-2(1H)-one-3-carboxylate 、 (Z)-2-diethoxycarbonyl-3-(2'-sec-butylphenyl)aminomethylene-benzochroman-4-one
  参考文献：
  名称：

  A versatile domino process for the synthesis of substituted 3-aminomethylene-chromanones and 2-pyridones catalyzed by CsF

  摘要：

  The addition of various primary amines onto 3-alpha,beta-unsaturated diester chromone derivative was studied under mild conditions. Basically, this reaction provided 2-pyridone-based compounds through an interesting domino 'Addition/Ring Opening/Ring Closure' process (ARORC). In this study, aniline and tryptamine series exhibited different reactivity profiles leading unexpectedly to 3-aminomethylene chromanones with or without the 2-pyridone derivatives. This constitutes the first description and study of 3-aminomethylene chromanone formation that is supposed to follow a domino process combining 'Addition/Ring Opening/Ring Closure by Oxa-Michael addition' (ARORCOM). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.03.096