2-(4-chlorophenyloxy)-2-(4-chlorophenyl)ethyl azide | 605680-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-chlorophenyloxy)-2-(4-chlorophenyl)ethyl azide
• 英文别名: 2-(4-chlorophenyloxy)-2-(4-chlorophenyl)ethylazide；1-[2-azido-1-(4-chlorophenoxy)ethyl]-4-chlorobenzene
• CAS: 605680-23-7
• 化学式: C₁₄H₁₁Cl₂N₃O
• 分子量: 308.167
• InChiKey: BLZSAAHPRSJYBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-chlorophenyloxy)-2-(4-chlorophenyl)ethyl azide 在 三甲基膦 、 lithium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.5h， 生成 2-(4-chlorophenoylxy)-2-(4-chlorophenyl)ethylamine
  参考文献：
  名称：

  [EN] ARALKYL AMINES AS CANNABINOID RECEPTOR MODULATORS
  [FR] ARALKYLAMINES UTILISEES EN TANT QUE MODULATEURS DES RECEPTEURS CANNABINOIDES

  摘要：

  具有结构公式(I)的新化合物是大麻素-1 (CB1)受体的拮抗剂和/或反向激动剂，在治疗、预防和抑制由CB1受体介导的疾病方面是有用的。本发明的化合物作为中枢作用药物，在治疗精神疾病、记忆缺陷、认知障碍、偏头痛、神经病、神经炎症性疾病（包括多发性硬化和吉兰-巴雷综合征）以及病毒性脑炎、脑血管意外和头部外伤的炎症后遗症、焦虑症、压力、癫痫、帕金森病、运动障碍和精神分裂症方面是有用的。这些化合物还用于治疗物质滥用障碍，包括酒精和尼古丁成瘾，治疗肥胖或饮食障碍，以及治疗哮喘、便秘、慢性假性肠梗阻和肝硬化。

  公开号：

  WO2005044785A1

文献信息

• [EN] SUBSTITUTED ARYL AMIDES<br/>[FR] ARYLAMIDES SUBSTITUEE
  申请人：MERCK & CO INC

  公开号：WO2003087037A1

  公开（公告）日：2003-10-23

  Novel compounds of structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as, the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

  结构式（I）的新化合物是大麻素-1（CB1）受体的拮抗剂和/或逆向激动剂，并且在治疗、预防和抑制由CB1受体介导的疾病方面具有用途。本发明的化合物可作为精神药物用于治疗精神病、记忆障碍、认知障碍、偏头痛、神经病、神经炎性疾病（包括多发性硬化和吉兰-巴雷综合征）以及病毒性脑炎、脑血管意外和头部创伤的炎症后遗症、焦虑症、压力、癫痫、帕金森病、运动障碍和精神分裂症。这些化合物还可用于治疗物质滥用障碍、肥胖症或进食障碍的治疗，以及哮喘、便秘、慢性肠假性梗阻和肝硬化的治疗。
• Aralkyl amines as cannabinoid receptor modulators
  申请人：Shah K. Shrenik

  公开号：US20070088058A1

  公开（公告）日：2007-04-19

  Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, including alcohol and nicotine addiction, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

  结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗、预防和抑制由CB1受体介导的疾病。本发明的化合物可用作中枢作用药物，用于治疗精神病、记忆障碍、认知障碍、偏头痛、神经病、神经炎性疾病（包括多发性硬化和格林-巴利综合症）、病毒性脑炎、脑血管意外和头部创伤的炎症后遗症、焦虑症、压力、癫痫、帕金森病、运动障碍和精神分裂症。该化合物还可用于治疗物质滥用障碍，包括酒精和尼古丁成瘾，治疗肥胖症或进食障碍，以及治疗哮喘、便秘、慢性肠假性梗阻和肝硬化。
• Substituted amides
  申请人：Merck Sharp & Dohme Corp.

  公开号：US07816534B2

  公开（公告）日：2010-10-19

  Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

  结构式（I）的新化合物是Cannabinoid-1（CB1）受体的拮抗剂和/或反向激动剂，并且可用于治疗、预防和抑制由CB1受体介导的疾病。本发明的化合物可用作中枢作用药物，用于治疗精神病、记忆障碍、认知障碍、偏头痛、神经病、神经炎性疾病，包括多发性硬化症和Guillain-Barre综合症以及病毒性脑炎、脑血管意外和头部创伤的炎症后遗症、焦虑症、压力、癫痫、帕金森病、运动障碍和精神分裂症。该化合物还可用于治疗物质滥用障碍、肥胖症或进食障碍，以及哮喘、便秘、慢性肠假性梗阻和肝硬化的治疗。
• [EN] SUBSTITUTED SULFONAMIDES<br/>[FR] SULFONAMIDES SUBSTITUES
  申请人：MERCK & CO INC

  公开号：WO2005027837A3

  公开（公告）日：2006-10-05
• US7390835B2
  申请人：——

  公开号：US7390835B2

  公开（公告）日：2008-06-24