2-Amino-1,9-dihydro-9-(2-C-methyl-D-ribofuranosyl)-6H-purin-6-one | 26097-97-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-Amino-1,9-dihydro-9-(2-C-methyl-D-ribofuranosyl)-6H-purin-6-one
• 英文别名: 2-amino-9-[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1H-purin-6-one
• CAS: 26097-97-2
• 化学式: C₁₁H₁₅N₅O₅
• 分子量: 297.27
• InChiKey: NVKAMPJSWMHVDK-CECVVVHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  155
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections
  申请人：Chamberlain Stanley

  公开号：US20120052046A1

  公开（公告）日：2012-03-01

  Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.

  本发明提供了从鸟嘌呤碱基衍生的磷酰胺化合物，具有增强的治疗效力，特别是对于治疗病毒感染，如丙型肝炎病毒，具有增强的效力。本发明还提供了制备该化合物的制药组合物、制备该化合物的方法以及使用该化合物和组合物治疗病毒感染的方法。
• SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS
  申请人：McGuigan Chris

  公开号：US20140140955A1

  公开（公告）日：2014-05-22

  This invention is directed to novel compounds of formula (I) having the structure (I) wherein U, V, W, Z, R 1 , X 1 , X 2 , and Y are defined herein. The compounds of formula (I) and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV).

  本发明涉及公式（I）的新化合物，其结构为（I），其中U、V、W、Z、R1、X1、X2和Y在此定义。公式（I）的化合物和包含这些化合物的制药组合物在哺乳动物中治疗由Flaviviridae病毒家族中的病毒介导的病毒感染中有用，特别是丙型肝炎病毒（HCV）。
• NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1773355B1

  公开（公告）日：2014-06-25
• COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：IDENIX Pharmaceuticals, Inc.

  公开号：EP2307434B1

  公开（公告）日：2014-02-12
• MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING
  申请人：ModernaTX, Inc.

  公开号：US20190225644A1

  公开（公告）日：2019-07-25

  The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.