(E)-benzyl(4-methylstyryl)sulfane | 1449331-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-benzyl(4-methylstyryl)sulfane
• 英文别名: 1-[(E)-2-benzylsulfanylethenyl]-4-methylbenzene
• CAS: 1449331-10-5
• 化学式: C₁₆H₁₆S
• 分子量: 240.369
• InChiKey: DODVMXMVVIOZCV-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯基甲烷磺酰肼 、 4-甲苯基乙炔 在 1,8-diazabicyclo[5.4.0]undec-7-en-8-ium acetate 、 溶剂黄146 作用下， 反应 0.08h， 以6%的产率得到
  参考文献：
  名称：

  Regioselective Hydrothiolation of Alkynes by Sulfonyl Hydrazides Using Organic Ionic Base–Brønsted Acid

  摘要：

  A practical and novel approach has been developed for the synthesis of vinyl sulfides by the reaction of sulfonyl hydrazides with aryl/heteroarylacetylenes using a DBU-based ionic liquid. The system offers a new sulfur source for hydrothiolation and is endowed with green credentials.

  DOI：

  10.1021/ol401925u

文献信息

• (E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
  申请人：——

  公开号：US20030149109A1

  公开（公告）日：2003-08-07

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

  使用α,β-不饱和芳基磺酮进行预处理可以保护正常细胞免受两类抗癌化疗药物的细胞毒副作用。在患者进行含细胞周期有丝分裂期抑制剂或拓扑异构酶抑制剂的抗癌化疗之前，给予一种细胞保护性磺酮化合物，可以减少或消除抗癌药物对正常细胞的细胞毒副作用。α,β-不饱和芳基磺酮的细胞保护作用使得临床医生可以安全地增加抗癌化疗药物的剂量。
• Decarbonylation of Salicylaldehyde Activated by<i>p</i>-Cymene Ruthenium(II) Dimer: Implication for Catalytic Alkyne Hydrothiolation
  作者：Sarangapani Modem、Shravankumar Kankala、Ramesh Balaboina、Narasimha Swamy Thirukovela、Sreekantha B. Jonnalagadda、Ravinder Vadde、Chandra Sekhar Vasam

  DOI：10.1002/ejoc.201600809

  日期：2016.9

  A stoichiometric C–H activation/decarbonylation of salicylaldehyde by [(η6-p-cymene)RuCl2]2 gave a carbonyl derivative [(η6-p-cymene)RuCl(CO)(Ph-O)] (1) without the use of CO gas. A variety of polar phosphines were then incorporated into compound 1 to give new RuII cationic catalysts, [(η6-p-cymene)Ru(CO)(Ph-O)L]BF4 (2–8). These were used to catalyse the hydrothiolation of alkynes with a range of thiols

  [(η6-p-cymene)RuCl2]2 化学计量的 C-H 活化/脱羰水杨醛得到羰基衍生物 [(η6-p-cymene)RuCl(CO)(Ph-O)] (1)，但不使用一氧化碳气体。然后将各种极性膦掺入化合物 1 中以得到新的 RuII 阳离子催化剂，[(η6-p-伞花烃)Ru(CO)(Ph-O)L]BF4 (2-8)。它们用于在四氢呋喃水溶液中催化炔烃与一系列硫醇的氢硫醇化反应，以高产率得到抗马尔科夫尼科夫 E-线性乙烯基硫化物。
• One-Pot Synthesis of Alkyl Styryl Sulfides Free from Transition Metal/Ligand Catalyst and Thiols
  作者：Adrián A. Heredia、Alicia B. Peñéñory

  DOI：10.1002/ejoc.201201163

  日期：2013.2

  developed. This methodology involves the in situ generation of thiolate anions by nucleophilic substitution between potassium thioacetate and alkyl halides followed by fragmentation. Further reactions of these thiolate anions with substituted (E,Z)-β-styryl halides gave the corresponding sulfides with retention of stereochemistry in good to excellent yields. This procedure does not require a metal catalyst

  开发了一种新的苯乙烯基烷基硫化物一锅合成方案。该方法涉及通过硫代乙酸钾和烷基卤化物之间的亲核取代，然后进行碎裂，原位生成硫醇盐阴离子。这些硫醇盐阴离子与取代的 (E,Z)-β-苯乙烯基卤化物的进一步反应得到相应的硫化物，并以良好至极好的产率保留立体化学。该过程不需要金属催化剂，它在温和的条件下和短时间内进行，并且它没有恶臭和对空气敏感的烷基硫醇。
• Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
  申请人：——

  公开号：US20040214903A1

  公开（公告）日：2004-10-28

  Pre-treatment with &agr;,&bgr; unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the &agr;,&bgr; unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.

  预处理使用α，β不饱和芳基磺酮可以保护正常细胞免受两类抗癌化疗药物的细胞毒副作用。在使用有丝分裂期细胞周期抑制剂或拓扑异构酶抑制剂的抗癌化疗前向患者给予细胞保护性磺酮化合物，可以减少或消除抗癌药物对正常细胞的细胞毒副作用。α，β不饱和芳基磺酮的细胞保护作用使临床医生可以安全地增加抗癌化疗药物的剂量。
• EP1180024A4
  申请人：——

  公开号：EP1180024A4

  公开（公告）日：2002-06-19