3-[2-(benzyloxy)phenyl]-3-hydroxy-3,5,6,7-tetrahydrocydrocyclopental[f]indol-2(1H)-one | 847866-67-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[2-(benzyloxy)phenyl]-3-hydroxy-3,5,6,7-tetrahydrocydrocyclopental[f]indol-2(1H)-one
• 英文别名: 3-[2-(benzyloxy)phenyl]-3-hydroxy-3,5,6,7-tetrahydrocyclopenta[f]indol-2(1H)-one；3-hydroxy-3-(2-phenylmethoxyphenyl)-1,5,6,7-tetrahydrocyclopenta[f]indol-2-one
• CAS: 847866-67-5
• 化学式: C₂₄H₂₁NO₃
• 分子量: 371.436
• InChiKey: GGZJTSJHKUZYOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,5,6,7-tetrahydro-cyclopent[f]indole-2,3-dione 在 magnesium 、 盐酸 作用下， 以 乙醚 、 四氢呋喃 、 水 为溶剂， 反应 18.0h， 生成 3-[2-(benzyloxy)phenyl]-3-hydroxy-3,5,6,7-tetrahydrocydrocyclopental[f]indol-2(1H)-one
  参考文献：
  名称：

  EP1659121

  摘要：

  公开号：

文献信息

• 1,3-Dihydro-2h-indol-2-one derivative
  申请人：Kumagai Toshihito

  公开号：US20060276449A1

  公开（公告）日：2006-12-07

  A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R 1 is a halogen atom, a C 1 to C 4 alkyl group, etc., and R 2 is a hydrogen atom, a halogen atom, etc., or R 2 is in the 6-position of the indol-2-one and R 1 and R 2 join together to form a C 3 to C 6 alkylene group, R 3 is a halogen atom, a hydroxyl group, etc., and R 4 is a hydrogen atom, a halogen atom, a C 1 to C 4 alkyl group, etc., or R 4 is in the 3-position of the phenyl and R 3 and R 4 join together to form a methylenedioxy group, R 5 is a hydrogen atom or a fluorine atom, R 6 is an ethylamino group, a dimethylamino group, etc., R 7 is a C 1 to C 4 alkoxy group, and R 8 is a C 1 to C 4 alkoxy group), or a pharmaceutically acceptable salt of this derivative. This is a novel compound that has antagonistic activity against an aruginine-vasopressin V1b receptor.

  公式1所表示的1,3-二氢吲哚-2-酮衍生物（其中R1是卤素原子、C1到C4烷基等，R2是氢原子、卤素原子等，或R2位于吲哚-2-酮的6位，且R1和R2结合形成C3到C6烷基，R3是卤素原子、羟基等，R4是氢原子、卤素原子、C1到C4烷基等，或R4位于苯环的3位，且R3和R4结合形成亚甲二氧基基团，R5是氢原子或氟原子，R6是乙基氨基基团、二甲基氨基基团等，R7是C1到C4烷氧基基团，R8是C1到C4烷氧基基团），或该衍生物的药学上可接受的盐。这是一种新型化合物，具有对抗arginine-vasopressin V1b受体的拮抗活性。
• 1,3-dihydro-2H-indol-2-one derivative
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：US07528124B2

  公开（公告）日：2009-05-05

  A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R1 is a halogen atom, a C1 to C4 alkyl group, etc., and R2 is a hydrogen atom, a halogen atom, etc., or R2 is in the 6-position of the indol-2-one and R1 and R2 join together to form a C3 to C6 alkylene group, R3 is a halogen atom, a hydroxyl group, etc., and R4 is a hydrogen atom, a halogen atom, a C1 to C4 alkyl group, etc., or R4 is in the 3-position of the phenyl and R3 and R4 join together to form a methylenedioxy group, R5 is a hydrogen atom or a fluorine atom, R6 is an ethylamino group, a dimethylamino group, etc., R7 is a C1 to C4 alkoxy group, and R8 is a C1 to C4 alkoxy group), or a pharmaceutically acceptable salt of this derivative. This is a novel compound that has antagonistic activity against an aruginine-vasopressin V1b receptor.

  公式1表示的是1,3-二氢吲哚-2-酮衍生物（其中R1是卤素原子、C1至C4烷基等，R2是氢原子、卤素原子等，或者R2位于吲哚-2-酮的6位，R1和R2结合形成C3至C6烷基，R3是卤素原子、羟基等，R4是氢原子、卤素原子、C1至C4烷基等，或者R4位于苯环的3位，R3和R4结合形成甲氧基二氧杂环丙基，R5是氢原子或氟原子，R6是乙基氨基基、二甲基氨基基等，R7是C1至C4烷氧基，R8是C1至C4烷氧基），或该衍生物的药学上可接受的盐。这是一种新型化合物，具有对抗arginine-vasopressin V1b受体的拮抗活性。
• US7528124B2
  申请人：——

  公开号：US7528124B2

  公开（公告）日：2009-05-05