3-[(3aR,3bS,5aS,8aS,8bS,10aS)-3a,5a-dimethyl-3,3b,4,5,8,8a,8b,9,10,10a-decahydro-2H-indeno[5,4-e][1]benzofuran-6-yl]-5-ethoxypyridine | 1315357-13-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[(3aR,3bS,5aS,8aS,8bS,10aS)-3a,5a-dimethyl-3,3b,4,5,8,8a,8b,9,10,10a-decahydro-2H-indeno[5,4-e][1]benzofuran-6-yl]-5-ethoxypyridine
• CAS: 1315357-13-1
• 化学式: C₂₄H₃₃NO₂
• 分子量: 367.532
• InChiKey: YAARBQRJAYWYFV-WBVSZOJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL CYP17 INHIBITORS
  申请人：Chu Daniel

  公开号：US20110178065A1

  公开（公告）日：2011-07-21

  Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.

  本文提供了CYP17酶的抑制剂。本文还描述了包括本文所述至少一种化合物的药物组合物，以及使用本文所述的化合物或药物组合物来治疗雄激素依赖性疾病、疾病和症状。
• [EN] NOVEL CYP17 INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE CYP17
  申请人：BIOMARIN PHARM INC

  公开号：WO2011088160A2

  公开（公告）日：2011-07-21

  Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.