3,5-bis(5-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,4,6-trimethyl-1,4-dihydropyridine | 1447968-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,5-bis(5-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,4,6-trimethyl-1,4-dihydropyridine
• CAS: 1447968-10-6
• 化学式: C₃₈H₃₅Br₂N₅
• 分子量: 721.537
• InChiKey: FOGTZDRNCOZWIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.31
• 重原子数：
  45.0
• 可旋转键数：
  6.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  43.23
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  3,5-丁二酮-2,4,6-三甲基-1,4-羟基吡啶 在 溶剂黄146 、 potassium hydroxide 作用下， 反应 4.0h， 生成 3,5-bis(5-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,4,6-trimethyl-1,4-dihydropyridine
  参考文献：
  名称：

  Synthesis, antibacterial and antifungal evaluation of novel 1,4-dihydropyridine derivatives

  摘要：

  3,5-Diacetyl-1,4-dihydro-2,4,6-trimethylpyridine (1) has been condensed with aromatic aldehydes to give the corresponding cinnamoyl derivatives IIa-e. the behavior of IIc, d towards thiourea, hydroxylamine hydrochloride, hydrazine hydrate and other bifunctional reagents has been investigated. The newly synthesized compounds were screened for their antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria and as antifungal reagent. Among all the tested compounds, it was found that compounds IIIa and Vila, b revealed better activity against the Gram-positive rather than the Gram-negative bacteria. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.12.069