1-allyl-4-phenylimidazole | 533915-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-allyl-4-phenylimidazole
• 英文别名: 4-Phenyl-1-prop-2-enylimidazole
• CAS: 533915-31-0
• 化学式: C₁₂H₁₂N₂
• 分子量: 184.241
• InChiKey: PMMBQXOZMPBQNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-allyl-4-phenylimidazole 、 对甲基苯甲酰氯 在 吡啶 作用下， 反应 5.0h， 以30%的产率得到(1-allyl-4-phenyl-1H-imidazole-2-yl)(4-methylphenyl)methanone
  参考文献：
  名称：

  NOVEL HETEROARYL DERIVATIVE

  摘要：

  公开号：

  EP1647546B1
• 作为产物：
  描述：

  4-苯基咪唑 、 3-溴丙烯 在 NaH 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 以88%的产率得到1-allyl-4-phenylimidazole
  参考文献：
  名称：

  11-O-substituted macrolides and their descladinose derivatives

  摘要：

  本文描述了11-O取代大环内酯及其去克拉迪酮衍生物，以及与药剂学上可接受的载体组合的治疗有效量的本发明化合物的制药组合物。还描述了通过向哺乳动物投予含有本发明化合物的治疗有效量的药物组合物来治疗细菌感染的方法，以及制备这些化合物的过程。

  公开号：

  US20030114396A1

文献信息

• Novel 11-O-substituted ketolide derivatives
  申请人：——

  公开号：US20030114395A1

  公开（公告）日：2003-06-19

  There are described novel 11-O-substituted ketolide derivatives of clarithromycin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

  本文描述了克拉霉素类似物的新型11-O取代酮类衍生物以及含有该发明化合物的治疗有效量与药学可接受载体组合的制药组合物的成分。还描述了通过向哺乳动物施用含有该发明化合物的治疗有效量的制药组合物来治疗细菌感染的方法，以及制备这种化合物的方法。
• 11-O-substituted macrolides and their descladinose derivatives
  申请人：——

  公开号：US20030114396A1

  公开（公告）日：2003-06-19

  There are described 11-O-substituted macrolides and their descladinose derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

  本文描述了11-O取代大环内酯及其去克拉迪酮衍生物，以及与药剂学上可接受的载体组合的治疗有效量的本发明化合物的制药组合物。还描述了通过向哺乳动物投予含有本发明化合物的治疗有效量的药物组合物来治疗细菌感染的方法，以及制备这些化合物的过程。
• [EN] NOVEL 11-O-SUBSTITUTED KETOLIDE DERIVATIVES<br/>[FR] NOUVEAUX DERIVES CETOLIDES SUBSTITUES EN 11-O
  申请人：ENANTA PHARM INC

  公开号：WO2003047601A1

  公开（公告）日：2003-06-12

  There are described novel 11-O-substituted ketolide derivatives of clarithromycin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

  本文介绍了一种新的11-O取代酮类衍生物，这些衍生物是克拉霉素类似物，并且包括一种治疗有效量的该化合物与药学上可接受的载体组合而成的药物成分。同时还介绍了一种通过给哺乳动物注射含有该化合物治疗有效量的药物组合物来治疗细菌感染的方法，以及制备这些化合物的过程。
• [EN] 11-O-SUBSTITUTED MACROLIDES AND THEIR DESCLADINOSE DERIVATIVES<br/>[FR] MACROLIDES SUBSTITUES EN 11-O ET LEURS DERIVES DESCLADINOSES
  申请人：ENANTA PHARM INC

  公开号：WO2003047600A1

  公开（公告）日：2003-06-12

  There are described 11-O-substituted macrolides and their descladinose derivatives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

  描述了11-O取代的大环内酯及其脱克拉多诺糖衍生物以及药学上可接受的组合物，其中包含本发明化合物的治疗有效量和药学上可接受的载体。还描述了一种通过向哺乳动物投予含有本发明化合物的治疗有效量的药物组合物来治疗细菌感染的方法，以及制备这些化合物的方法。
• Method for immunochemical measurement
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0047470A1

  公开（公告）日：1982-03-17

  A method for immunochemical assay of an antigen or antibody by labelling the antigen or antibody with a specific cyanine or merocyanine dye containing a carboxy group followed by effecting an immune reaction and photochemical processing thereof is provided. The amount of the antigen or antibody is measured in term of optical density of developed silver halide which is brought into contact with either the antigen-antibody reaction product or the unreacted material. This immunochemial assay method gives high detection sensitivity in a simple operation manner.

  本发明提供了一种对抗原或抗体进行免疫化学检测的方法，即用含有羧基的特异性青色或梅洛青染料标记抗原或抗体，然后对其进行免疫反应和光化学处理。 抗原或抗体的量是通过与抗原-抗体反应产物或未反应物质接触的显影卤化银的光密度来测量的。 这种免疫化学检测方法操作简单，检测灵敏度高。