2-辛基-2-炔丙基丙二酸 | 100964-55-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-辛基-2-炔丙基丙二酸
• 英文名称: 2-octyl-2-propargylmalonic acid
• 英文别名: octyl-prop-2-ynyl-malonic acid；Octyl-prop-2-inyl-malonsaeure；2-Octyl-2-prop-2-ynylpropanedioic acid
• CAS: 100964-55-4
• 化学式: C₁₄H₂₂O₄
• 分子量: 254.326
• InChiKey: LMUVQAJMSFNCKR-UHFFFAOYSA-N

物化性质

• 沸点：
  413.9±40.0 °C(Predicted)
• 密度：
  1.092±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-辛基-2-炔丙基丙二酸 在 zinc(II) carbonate 作用下， 生成 2-acetonyl-decanoic acid anilide
  参考文献：
  名称：

  Zur Kenntnis der Acetylencarbonsäuren. IX. Mitteilung: Die Bildung ungesättigter Lactone aus Alkinsäuren

  摘要：

  DOI：

  10.1002/ardp.19582910505
• 作为产物：
  描述：

  2-辛基-2-炔丙基丙二酸二乙酯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以97%的产率得到2-辛基-2-炔丙基丙二酸
  参考文献：
  名称：

  Design, Synthesis, and Structure−Activity Relationships of Haloenol Lactones:  Site-Directed and Isozyme-Selective Glutathione S-Transferase Inhibitors

  摘要：

  Overexpression of glutathione S-transferase (GST), particularly the GST-pi isozyme, has been proposed to be one of the biochemical mechanisms responsible for drug resistance in cancer chemotherapy, and inhibition of overexpressed GST has been suggested as an approach to combat GST-induced drug resistance. 3-Cinnamyl-5(E)-bromomethylidenetetrahydro-2-furanone (1a), a lead compound of site-directed GST-pi inactivator, has been shown to potentiate the cytotoxic effect of cisplatin on tumor cells. As an initial step to develop more potent and more selective haloenol lactone inactivators of GST-pi, we examined the relationship between the chemical structures of haloenol lactone derivatives and their GST inhibitory activity. A total of 16 haloenol lactone derivatives were synthesized to probe the effects of (1) halogen electronegativity, (2) electron density of aromatic rings, (3) molecular size and rigidity, (4) lipophilicity, and (5) aromaticity on the potency of GST-pi inactivation. The inhibitory potency of each compound was determined by time-dependent inhibition tests, and recombinant human GST-pi was used to determine their inhibitory activity. Our structure-activity relationship studies demonstrated that (1) reactivity of the halide leaving group plays a weak role in GST inactivation by the haloenol lactones, (2) aromatic electron density may have some influence on the potency of GST inactivation, (3) high rigidity likely disfavors enzyme inhibition, (4) lipophilicity is inversely proportional to enzyme inactivation, and (5) an unsaturated system may be important for enzyme inhibition. This work facilitated understanding of the interaction of GST-pi with haloenol lactone derivatives as site-directed and isozyme-selective inactivators, possibly potentiating cancer chemotherapy.

  DOI：

  10.1021/jm0499615