5-(2-Methoxyethyl)-5-[4-(3-methylbenzimidazol-5-yl)oxyphenoxy]-1,3-diazinane-2,4,6-trione | 620989-41-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(2-Methoxyethyl)-5-[4-(3-methylbenzimidazol-5-yl)oxyphenoxy]-1,3-diazinane-2,4,6-trione
• CAS: 620989-41-5
• 化学式: C₂₁H₂₀N₄O₆
• 分子量: 424.413
• InChiKey: OZBWSCTYTSYIBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] PYRIMIDINE-2, 4, 6-TRIONE METALLO-PROTEINASE INHIBITORS<br/>[FR] INHIBITEURS DE METALLOPROTEINASE A BASE DE PYRIMIDINE-2, 4, 6-TRIONE
  申请人：PFIZER PROD INC

  公开号：WO2003090751A1

  公开（公告）日：2003-11-06

  The present invention relates to N-substituted-heteroaryloxy-aryloxy-2, 4, 6-trione metalloproteinase inhibitors of the formula (I) wherein X, A, Y, B, G and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders. The compounds are matrix metalloproteinase (MMP) inhibitors.