(4S,5S,2'S)-5-(3'-azido-1'-hydroxy-2'-propyl)-4-(cyclohexylmethyl)oxazolidin-2-one | 120477-07-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S,5S,2'S)-5-(3'-azido-1'-hydroxy-2'-propyl)-4-(cyclohexylmethyl)oxazolidin-2-one
• 英文别名: (4S,5S)-5-[(2S)-1-azido-3-hydroxypropan-2-yl]-4-(cyclohexylmethyl)-1,3-oxazolidin-2-one
• CAS: 120477-07-8
• 化学式: C₁₃H₂₂N₄O₃
• 分子量: 282.343
• InChiKey: DXRWDJTVGDOEPJ-SRVKXCTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.35
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  107.32
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (4S,5S,2'S)-5-(3'-azido-1'-hydroxy-2'-propyl)-4-(cyclohexylmethyl)oxazolidin-2-one 在 barium dihydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以91%的产率得到(2S,3S,4S)-4-amino-1-azido-5-cyclohexyl-3-hydroxy-2-(hydroxymethyl)pentane
  参考文献：
  名称：

  Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue

  摘要：

  Azidomethyl-substituted 1,2- and 1,3-diols were prepared from Boc-cyclohexylalanal and evaluated as transition state analogue renin inhibitors, leading to the development of a small (MW less than 600), nanomolar inhibitor. Remarkable aqueous solubility enhancement followed the incorporation of an N-terminal urea functionality. Evaluation of selected compounds both in vivo and in vitro demonstrated that while transport across the intestine occurred upon id administration, extensive liver extraction resulted in low systemic levels.

  DOI：

  10.1021/jm00126a038
• 作为产物：
  描述：

  (4S,5S)-4-(cyclohexylmethyl)-5-(3',3'-diethoxy-2'-propenyl)oxazolidin-2-one 在 咪唑 、 sodium hydroxide 、 sodium tetrahydroborate 、 sodium azide 、 硼烷 、 四丁基氟化铵 、 双氧水 、 草酸 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 38.0h， 生成 (4S,5S,2'S)-5-(3'-azido-1'-hydroxy-2'-propyl)-4-(cyclohexylmethyl)oxazolidin-2-one
  参考文献：
  名称：

  Azido glycols: potent, low molecular weight renin inhibitors containing an unusual post scissile site residue

  摘要：

  Azidomethyl-substituted 1,2- and 1,3-diols were prepared from Boc-cyclohexylalanal and evaluated as transition state analogue renin inhibitors, leading to the development of a small (MW less than 600), nanomolar inhibitor. Remarkable aqueous solubility enhancement followed the incorporation of an N-terminal urea functionality. Evaluation of selected compounds both in vivo and in vitro demonstrated that while transport across the intestine occurred upon id administration, extensive liver extraction resulted in low systemic levels.

  DOI：

  10.1021/jm00126a038

文献信息

• ROSENBERG, SAUL H.;WOODS, KEITH W.;KLEINERT, HOLLIS D.;STEIN, HERMAN;NELL+, J. MED. CHEM., 32,(1989) N, C. 1371-1378
  作者：ROSENBERG, SAUL H.、WOODS, KEITH W.、KLEINERT, HOLLIS D.、STEIN, HERMAN、NELL+

  DOI：——

  日期：——