1-(2,4-dibromo-5-methoxyphenyl)ethanone | 54826-15-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,4-dibromo-5-methoxyphenyl)ethanone
• CAS: 54826-15-2
• 化学式: C₉H₈Br₂O₂
• 分子量: 307.969
• InChiKey: JJXSKMOCYYYVNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  13.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  3-甲氧基苯乙酮 在 五氧化二碘 、 potassium bromide 作用下， 以 水 为溶剂， 反应 66.0h， 以24%的产率得到1-(2,4-dibromo-5-methoxyphenyl)ethanone
  参考文献：
  名称：

  Bromination of Arenes Using I₂O₅-KBr in Water

  摘要：

  An efficient and environmentally benign bromination of various aromatic compounds using aN aqueous I2O5-KBr system at room temperature has been developed in this work. A series of aromatic compounds such as acetophenones, benzaldehydes, benzoic acids, anilines, amides, and aminopyridine have been successfully brominated in excellent regioselectivities and good yields under the typical reaction conditions. The features of KBr as brominating reagent, water as solvent, and mild conditions make this system an attractive synthetic procedure. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.796523