3-氨基-2-苯甲酰基-6-氧代-6H，7H-噻吩并[2,3-b]吡啶-5-羧酸 | 439946-22-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-氨基-2-苯甲酰基-6-氧代-6H，7H-噻吩并[2,3-b]吡啶-5-羧酸
• 英文名称: 3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
• 英文别名: LDN-91946；3-amino-2-benzoyl-6-oxo-6H,7H-thieno[2,3-b]pyridine-5-carboxylic acid；3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid
• CAS: 439946-22-2
• 化学式: C₁₅H₁₀N₂O₄S
• mdl: MFCD03016619
• 分子量: 314.321
• InChiKey: OJHMDRZMENMQFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-溴苯乙酮 、 5-cyano-2-oxo-6-sulfanyl-1,2-dihydropyridine-3-carboxylic acid 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 48.0h， 以50%的产率得到3-氨基-2-苯甲酰基-6-氧代-6H，7H-噻吩并[2,3-b]吡啶-5-羧酸
  参考文献：
  名称：

  摘要：

  Simple methods for the synthesis of previously unknown sulfur-containing pyridia-2-ones and 5,6,7,8-tetrahydroquinolines from cyanothioacetamide and anilinomethylidene derivatives of cyclic 1,3-dicarbonyl compounds were developed. Structures and chemical transformations of compounds obtained were studied.

  DOI：

  10.1023/a:1020939712830

文献信息

• Protein degradation inducing tag and usage thereof
  申请人：Tokyo University of Science Foundation

  公开号：US10976306B2

  公开（公告）日：2021-04-13

  Provided are: a protein degradation inducing tag which is a molecule that has affinity with proteases and does not inhibit degradation of a protein by proteases; a protein degradation inducing molecule that is a conjugate of at least one protein degradation inducing tag and at least one protein binding molecule that binds to a protein; and a usage of those.

  提供了：一种蛋白质降解诱导标签，它是一种与蛋白酶具有亲和力的分子，不会抑制蛋白酶对蛋白质的降解；一种蛋白质降解诱导分子，它是至少一种蛋白质降解诱导标签和至少一种与蛋白质结合的蛋白质结合分子的共轭物；以及它们的用法。
• P53 degradation inducing molecule and pharmaceutical composition
  申请人：Tokyo University of Science Foundation

  公开号：US11007269B2

  公开（公告）日：2021-05-18

  A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.

  本发明提供了一种可诱导 p53 蛋白或 p53 复合物降解的 p53 降解诱导分子，以及一种含有所述 p53 降解诱导分子的药物组合物。这种 p53 降解诱导分子是对 p53 蛋白质或 p53 复合物具有亲和力的 p53 亲和分子与对蛋白酶具有亲和力且不抑制蛋白酶对蛋白质的蛋白水解的蛋白水解诱导标签的共轭物。
• Ras protein degradation inducing molecule and pharmaceutical composition
  申请人：Tokyo University of Science Foundation

  公开号：US11052154B2

  公开（公告）日：2021-07-06

  A Ras protein degradation inducing molecule that can induce degradation of Ras proteins, and a pharmaceutical composition that contains this Ras protein degradation inducing molecule are provided. The Ras protein degradation inducing molecule is a conjugate of a Ras protein affinity molecule which has affinity to Ras proteins, and a proteolysis-inducing tag which has affinity to protease and does not inhibit proteolysis of proteins by the protease.

  本发明提供了一种可诱导 Ras 蛋白降解的 Ras 蛋白降解诱导分子，以及一种含有这种 Ras 蛋白降解诱导分子的药物组合物。Ras 蛋白降解诱导分子是与 Ras 蛋白亲和的 Ras 蛋白亲和分子和与蛋白酶亲和的蛋白水解诱导标签的共轭物，蛋白水解诱导标签不抑制蛋白酶对蛋白质的蛋白水解。
• Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US11136409B2

  公开（公告）日：2021-10-05

  The present invention is based, in part, on the identification of novel USP10 biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating AML.

  本发明部分基于新型 USP10 生物标记物和调节剂的鉴定及其使用方法，用于鉴定、评估、预防和治疗急性髓细胞白血病。
• PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF
  申请人：Tokyo University of Science Foundation

  公开号：US20180164289A1

  公开（公告）日：2018-06-14

  Provided are: a protein degradation inducing tag which is a molecule that has affinity with proteases and does not inhibit degradation of a protein by proteases; a protein degradation inducing molecule that is a conjugate of at least one protein degradation inducing tag and at least one protein binding molecule that binds to a protein; and a usage of those.