| 1227850-88-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1227850-88-5
• 化学式: C₁₃H₂₁NO₅
• 分子量: 271.313
• InChiKey: VYFKXPHGFOEDLB-UXCLJVHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.55
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  66.02
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  ethyl-1,2-O-isopropylidene-α-D-xylo-furanuronyl benzotriazole 、 环丙胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以88%的产率得到
  参考文献：
  名称：

  Facile Synthesis of Novel Glycosyl Carboxamide with Sugar in Furanose and Pyranose form Using Benzotriazole Methodology

  摘要：

  There is an increased demand for significant amounts of carbohydrate based molecules for complete biological, medicinal, and pharmacological investigations where tremendous efforts have been made to develop novel and facile procedure for the synthesis of glycoconjugates and diverse carboxamides. Limitations with the common approaches for amide bond formation, including use of hazardous chemicals, long reaction times, low reaction yields, frequently require strong basic catalysts, strictly anhydrous conditions, harsh reaction conditions, expensive and limited availability of coupling materials, and moreover the less stability of activated acids warrant the search of a simple, short, and high yielding amide bond synthetic methodology. Herein, a facile and high yielding synthesis of novel glycosyl carboxamide with both furanose and pyranose sugar using benzotriazole methodology has been developed under mild conditions.

  DOI：

  10.2174/157017810790796363