2-乙酰氨基-2-脱氧-D-半乳糖酰胺 | 93790-40-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-乙酰氨基-2-脱氧-D-半乳糖酰胺
• 英文名称: 2-Acetamido-2-deoxygalacturonamide
• 英文别名: (2S,3R,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxohexanamide
• CAS: 93790-40-0
• 化学式: C₈H₁₄N₂O₆
• 分子量: 234.21
• InChiKey: RVSLEPKUAJVXHK-WNJXEPBRSA-N

物化性质

• 沸点：
  781.5±60.0 °C(Predicted)
• 密度：
  1.476±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates
  申请人：Northwestern University

  公开号：US10829795B2

  公开（公告）日：2020-11-10

  Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

  所公开的是无细胞合成糖基化蛋白质的方法、系统、组件和组合物。糖基化蛋白质可用于疫苗，包括抗菌疫苗。糖基化蛋白质可包括与载体共轭的细菌多糖，可用于在免疫宿主中产生针对与载体共轭的多糖的免疫反应。糖基化蛋白质可在无细胞糖蛋白合成（CFGpS）系统中合成，该系统使用富含糖蛋白合成成分的原核细胞裂解物，如低聚糖转移酶（OST）和脂联低聚糖（LLO），包括与合成细菌 O 抗原有关的 OST 和 LLO。
• Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
  申请人：Northwestern University

  公开号：US11530432B2

  公开（公告）日：2022-12-20

  Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

  所公开的是无细胞合成糖基化载体蛋白的方法、系统、组件和组合物。糖基化载体蛋白可用于疫苗，包括抗菌疫苗。糖基化载体蛋白可包括与载体共轭的细菌多糖，可用于在免疫宿主中产生针对与载体共轭的多糖的免疫反应。糖基化载体蛋白可在无细胞糖蛋白合成（CFGpS）系统中合成，该系统使用富含糖蛋白合成成分的原核细胞裂解物，如低聚糖转移酶（OST）和脂联低聚糖（LLO），包括与合成细菌 O 抗原有关的 OST 和 LLO。
• IMMUNOGENIC SEQUENCES
  申请人：THE SECRETARY OF STATE FOR DEFENCE

  公开号：EP1509607B1

  公开（公告）日：2013-02-20
• BIOCONJUGATES COMPRISING MODIFIED ANTIGENS AND USES THEREOF
  申请人：Glycovaxyn AG

  公开号：EP2892566A1

  公开（公告）日：2015-07-15
• BIOCONJUGATE VACCINES' SYNTHESIS IN PROKARYOTIC CELL LYSATES
  申请人：Northwestern University

  公开号：EP3908669A1

  公开（公告）日：2021-11-17