2-(1'-methoxy)methyl-1-methylimidazole | 1667730-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(1'-methoxy)methyl-1-methylimidazole
• 英文别名: 2-(methoxymethyl)-1-methylimidazole；2-(Methoxymethyl)-1-methyl-1H-imidazole
• CAS: 1667730-79-1
• 化学式: C₆H₁₀N₂O
• 分子量: 126.158
• InChiKey: VWJPRLSGBMZWAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1'-methoxy)methyl-1-methylimidazole 以 水 、 乙腈 为溶剂， 反应 24.0h， 生成 3-ethyl-2-(methoxymethyl)-1-methylimidazolium acetate
  参考文献：
  名称：

  셀룰로오스 분해율이 낮은 이온성 액체

  摘要：

  This invention relates to an ionic liquid with a low cellulose degradation rate. According to the invention, the ionic liquid has a solubility of cellulose that is similar or even superior to that of commercial ionic liquids, and the cellulose degradation rate during dissolution is significantly low. This has the beneficial effect of maintaining mechanical properties close to the original cellulose.

  公开号：

  KR20160096254A
• 作为产物：
  描述：

  1-甲基-2-羟甲基-1H-咪唑 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 40.0h， 以85%的产率得到2-(1'-methoxy)methyl-1-methylimidazole
  参考文献：
  名称：

  셀룰로오스 분해율이 낮은 이온성 액체

  摘要：

  This invention relates to an ionic liquid with a low cellulose degradation rate. According to the invention, the ionic liquid has a solubility of cellulose that is similar or even superior to that of commercial ionic liquids, and the cellulose degradation rate during dissolution is significantly low. This has the beneficial effect of maintaining mechanical properties close to the original cellulose.

  公开号：

  KR20160096254A

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS<br/>[FR] COMPOSES ET COMPOSITIONS UTILISES COMME INHIBITEURS DE LA CATHEPSINE S
  申请人：NOVARTIS AG

  公开号：WO2006018284A1

  公开（公告）日：2006-02-23

  The present invention relates to the use of a 2-cyanopyrimidine compound of the formula (I), wherein R1, R2, R3 and X are as defined in the specification and in the claims, in free form or in salt form, and , where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.

  本发明涉及使用式(I)的2-氰基嘧啶化合物，其中R1、R2、R3和X如规范和权利要求中定义的那样，以自由形式或盐形式，并在可能的情况下以互变异构形式，作为猫hepsin S活性的抑制剂。
• ELECTRONIC DEVICE COMPRISING METAL COMPLEXES
  申请人：Stoessel Philipp

  公开号：US20120286254A1

  公开（公告）日：2012-11-15

  The present invention relates to electronic devices, in particular organic electroluminescent devices, comprising metal complexes of the formula (1), and to the preferred metal complexes.

  本发明涉及电子设备，特别是有机电致发光器件，包括具有式（1）的金属配合物，以及优选的金属配合物。
• [EN] BENZODIAZEPINE COMPOUNDS USEFUL FOR THE TREATMENT OF HEPATITIS C<br/>[FR] COMPOSÉS DE BENZODIAZÉPINE UTILES POUR LE TRAITEMENT DE L'HÉPATITE C
  申请人：ARROW THERAPEUTICS LTD

  公开号：WO2011151651A1

  公开（公告）日：2011-12-08

  The invention concerns benzodiazepine derivatives of Formula (I) wherein A, X, L1, L2, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.

  这项发明涉及式（I）的苯二氮卓啉衍生物，其中A、X、L1、L2、R1、R2、R3、R4、R5、R6和R7如描述中所定义。本发明还涉及制备这类化合物的方法、含有它们的药物组合物以及它们在治疗或预防丙型肝炎病毒感染中的用途。
• COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS
  申请人：Hart Terance William

  公开号：US20090048230A1

  公开（公告）日：2009-02-19

  The present invention relates to the use of a 2-cyanopyrimidine compound of the formula wherein R 1 , R 2 , R 3 and X are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.

  本发明涉及使用式中R1、R2、R3和X如规范和权利要求中定义的2-氰基嘧啶化合物的自由形式或盐形式及在可能的情况下互变异构体形式，作为猫hepsin S活性的抑制剂。
• FACTOR Xa INHIBITORS
  申请人：Jia Zhaozhong J.

  公开号：US20080293704A1

  公开（公告）日：2008-11-27

  The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat certain conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

  本发明涉及由公式（I）表示的化合物或其药学上可接受的盐、酯或前药，其为Xa因子的抑制剂。本发明还涉及用于制备这种化合物的中间体，包含这种化合物的制药组合物，预防或治疗某些由不希望的血栓形成所表现出的病症的方法，以及抑制血样的凝血作用的方法。