2-[(6-azidohexyloxy)methyl]-2-(hydroxymethyl)propane-1,3-diol | 1421958-51-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(6-azidohexyloxy)methyl]-2-(hydroxymethyl)propane-1,3-diol
• 英文别名: 2-(6-Azidohexoxymethyl)-2-(hydroxymethyl)propane-1,3-diol
• CAS: 1421958-51-1
• 化学式: C₁₁H₂₃N₃O₄
• 分子量: 261.321
• InChiKey: ATBCWOHFZOBABR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  84.3
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-((6-azidohexyloxy)methyl)-1-methyl-2,6,7-trioxabicyclo[2.2.2]octane 在 盐酸 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 7.0h， 以42.3%的产率得到2-[(6-azidohexyloxy)methyl]-2-(hydroxymethyl)propane-1,3-diol
  参考文献：
  名称：

  Sub-10 nm Nano-Organization in AB₂- and AB₃-Type Miktoarm Star Copolymers Consisting of Maltoheptaose and Polycaprolactone

  摘要：

  The AB(2)- and AB(3)-type miktoarm star copolymers consisting of maltoheptaose (MH, as A block) and poly(epsilon-caprolactone) (PCL, as B block), namely MH-b-(PCL)(2) and MH-b-(PCL)(3), were synthesized, and their nano-organization was characterized. The syntheses of MHb-(PCL)(2) and MH-b-(PCL)(3) were carried out through two reaction steps: (1) preparation of linear and three-branched PCLs bearing an azido group on the chain center (N-3-(PCL)(2) and N-3-(PCL)(3)) by the diphenyl phosphate-catalyzed ring-opening polymerization of epsilon-caprolactone (epsilon-CL) using azido-functionalized di- and triols (N-3-(OH)(2) and N-3-(OH)(3)) as the initiators and (2) the copper-catalyzed azide-alkyne cycloaddition of N-3-(PCL)(2) and N-3-(PCL)(3) with the ethynyl-functionalized MH. The miktoarm star copolymers having M-n for the PCL block of ca. 5000 (MH-b-(PCL2.5k)(2) and MH-b-(PCL1.7k)(3)) and 10 000 (MH-b-(PCL5k)(2) and MH-b-(PCL3.3k)(3)) were obtained with a very narrow polydispersity index of less than 1.05. Bulk samples of the four types of miktoarm star copolymers exhibited body centered cubic phases, as determined by small angle X-ray diffraction experiments. The domain spacing were determined to be 9.8 nm for MH-b-(PCL2.5k)(2), 8.8 nm for MH-b-(PCL1.7k)(3), 10.5 nm for MH-b-(PCL5k)(2), and 9.8 nm for MH-b-(PCL3.3k)(3), which were smaller than those of the corresponding linear diblock copolymers.

  DOI：

  10.1021/ma3026578