(3aR,4R,6R,6aR)-6-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-N-hydroxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxamidine | 252760-57-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (3aR,4R,6R,6aR)-6-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-N-hydroxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxamidine
• 英文别名: (3aR,4R,6R,6aR)-4-[2-chloro-6-(2,2-diphenylethylamino)purin-9-yl]-N'-hydroxy-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole-6-carboximidamide
• CAS: 252760-57-9
• 化学式: C₂₇H₂₈ClN₇O₄
• 分子量: 550.017
• InChiKey: SLWMKMAZXAQUTQ-FBROZUCGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP1090023B1

  公开（公告）日：2003-09-10
• [EN] 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES<br/>[FR] DERIVES DU 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4 DIOL
  申请人：GLAXO GROUP LIMITED

  公开号：WO1999067264A1

  公开（公告）日：1999-12-29

  (EN) There are provided according to the invention novel compounds of formula (I), wherein R1, R2, R3, Z1, Z2, Z3 and Z4 are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.(FR) L'invention porte sur de nouveaux composés de formule (I) dans laquelle R1, R2, Z1, Z2, Z3 et Z4 sont définis dans la description, sur leurs procédés d'obtention, sur des préparations les contenant, et sur leur utilisation pour le traitement de maladies à caractère inflammatoire.