3-(4-{(2S,3S,4S,5R)-5-[3-{2-chloro-4-[(methyl-napthalen-1-ylmethyl-amino)-methyl]-phenoxy}-1-methyl-(1E)-propenyl]-3,4-dihydroxy-tetrahydro-furan-2-yloxy}-3-hydroxy-phenyl)-2-methyl-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxy-hexahydro-benzo[1,3]dioxol-5-yl)-(2E)-acrylamide | 377069-25-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4-{(2S,3S,4S,5R)-5-[3-{2-chloro-4-[(methyl-napthalen-1-ylmethyl-amino)-methyl]-phenoxy}-1-methyl-(1E)-propenyl]-3,4-dihydroxy-tetrahydro-furan-2-yloxy}-3-hydroxy-phenyl)-2-methyl-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxy-hexahydro-benzo[1,3]dioxol-5-yl)-(2E)-acrylamide
• 英文别名: (E)-N-[(3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxy-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxol-5-yl]-3-[4-[(2S,3S,4S,5R)-5-[(E)-4-[2-chloro-4-[[methyl(naphthalen-1-ylmethyl)amino]methyl]phenoxy]but-2-en-2-yl]-3,4-dihydroxyoxolan-2-yl]oxy-3-hydroxyphenyl]-2-methylprop-2-enamide
• CAS: 377069-25-5
• 化学式: C₄₄H₄₉ClN₂O₁₂
• 分子量: 833.332
• InChiKey: AXROJQYVIOJLTA-HYQBOEPCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  59
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  200
• 氢给体数：
  7
• 氢受体数：
  13

文献信息

• Hygromycin a derivatives
  申请人：——

  公开号：US20030045528A1

  公开（公告）日：2003-03-06

  This invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 and R 10 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1, methods of treating bacterial and protozoal infections by administering the compounds of formula 1.

  本发明涉及公式1的化合物及其药学上可接受的盐、前药和溶剂化物，其中R1、R2、R3和R10如本文所定义。公式1的化合物是抗菌和抗原虫剂，可用于治疗各种细菌和原虫感染以及与此类感染相关的疾病。本发明还涉及含有公式1的化合物的制药组合物，以及通过给予公式1的化合物来治疗细菌和原虫感染的方法。
• HYGROMYCIN A DERIVATIVES FOR THE TREATMENT OF BACTERIAL AND PROTOZOAL INFECTIONS
  申请人：Pfizer Products Inc.

  公开号：EP1287011A1

  公开（公告）日：2003-03-05
• JP2003535100A
  申请人：——

  公开号：JP2003535100A

  公开（公告）日：2003-11-25
• US6867230B2
  申请人：——

  公开号：US6867230B2

  公开（公告）日：2005-03-15
• [EN] HYGROMYCIN A DERIVATIVES FOR THE TREATMENT OF BACTERIAL AND PROTOZOAL INFECTIONS<br/>[FR] DERIVES DE L'HYGROMYCINE A POUR LE TRAITEMENT D'INFECTIONS BACTERIENNES ET PROTOZOOSES
  申请人：PFIZER PROD INC

  公开号：WO2001092280A1

  公开（公告）日：2001-12-06

  This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R?1, R2, R3 and R10¿ are as defined herein. The compounds of formula (1) are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1), methods of treating bacterial and protozoal infections by administering the compounds of formula (1).