2-(2,4,6-Trimethylanilino)ethyl imidazole-1-carboxylate | 1371582-11-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2,4,6-Trimethylanilino)ethyl imidazole-1-carboxylate
• CAS: 1371582-11-4
• 化学式: C₁₅H₁₉N₃O₂
• 分子量: 273.335
• InChiKey: LXYAMJUOIPMRCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  56.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2,4,6-Trimethylanilino)ethyl imidazole-1-carboxylate 在 吡啶盐酸盐 作用下， 以 乙腈 为溶剂， 反应 9.0h， 以0.09 g的产率得到N-(2,4,6-trimethylphenyl)oxazolidin-2-one
  参考文献：
  名称：

  Dual Brønsted Acid/Nucleophilic Activation of Carbonylimidazole Derivatives

  摘要：

  Carbonylimidazole derivatives have been found to be highly active acylation reagents for esterification and amidation in the presence of pyridinium salts. These reactions are thought to involve both Bronsted acid and nucleophilic catalysis. This mode of activation has been applied to the synthesis of difficult to access oxazolidinones, as well as esters and amides. Finally, the use of pyridinium salts has been shown to accelerate the esterification of carboxylic acids with imidazole carbamates.

  DOI：

  10.1021/ol300339q
• 作为产物：
  描述：

  2-<2,4,6-Trimethyl-anilino>-aethanol 、 N,N'-羰基二咪唑 以 二氯甲烷 为溶剂， 生成 2-(2,4,6-Trimethylanilino)ethyl imidazole-1-carboxylate
  参考文献：
  名称：

  Dual Brønsted Acid/Nucleophilic Activation of Carbonylimidazole Derivatives

  摘要：

  Carbonylimidazole derivatives have been found to be highly active acylation reagents for esterification and amidation in the presence of pyridinium salts. These reactions are thought to involve both Bronsted acid and nucleophilic catalysis. This mode of activation has been applied to the synthesis of difficult to access oxazolidinones, as well as esters and amides. Finally, the use of pyridinium salts has been shown to accelerate the esterification of carboxylic acids with imidazole carbamates.

  DOI：

  10.1021/ol300339q