bis-(3-mercapto-propyl)-ether | 13406-87-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: bis-(3-mercapto-propyl)-ether
• 英文别名: 3.3'-Dimercapto-dipropylaether；Bis-(3-mercapto-propyl)-aether；3-(3-Sulfanylpropoxy)propane-1-thiol
• CAS: 13406-87-6
• 化学式: C₆H₁₄OS₂
• 分子量: 166.309
• InChiKey: IFVYLGBXAXTHSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  11.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫化氢铵 、 乙醇 作用下， 生成 bis-(3-mercapto-propyl)-ether
  参考文献：
  名称：

  Simpson, Canadian Journal of Research, Section B: Chemical Sciences, 1947, vol. 25, p. 25

  摘要：

  DOI：

文献信息

• [EN] BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME<br/>[FR] LIGANDS BROMODOMAINES BIVALENTS ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：COFERON INC

  公开号：WO2015081284A1

  公开（公告）日：2015-06-04

  Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on different proteins. For example, in one aspect, a bivalent compound or a pharmaceutically acceptable salt, stereoisomer, metabolite, or hydrate thereof is provided. In another aspect, a method of treating a disease associated with a protein having tandem bromodomains in a patient in need thereof is provided. The method comprises administering to the patient the bivalent compound as described.

  本文描述了一种能够同时调节一个或多个生物分子的化合物，例如，在蛋白质上或在不同蛋白质上调节两个或更多结合结构域（例如溴结构域）。例如，在一个方面，提供了一种二价化合物或药用盐、立体异构体、代谢物或其水合物。在另一个方面，提供了一种治疗与患有串联溴结构域蛋白相关的疾病的方法，该方法包括向患者注射所述的二价化合物。
• METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID
  申请人：Shiba Yoshinobu

  公开号：US20090149645A1

  公开（公告）日：2009-06-11

  A method is provided for removing a 2-cyanoethoxymethyl (CEM) group and substituting the 2′-hydroxyl group of each ribose of an oligonucleic acid derivative with good reproducibility and high efficiency.

  提供了一种方法，用于去除2-氰乙氧甲基（CEM）基团，并将寡核苷酸衍生物的每个核糖的2'-羟基以良好的可重复性和高效率进行置换。
• Thiophosphine compounds and methods of making polymerizable compositions containing them and their use for making ophthalmic lenses
  申请人：Wanigatunga Sirisoma

  公开号：US20050107579A1

  公开（公告）日：2005-05-19

  Thiophosphine compounds (also named phosphine sulfide compounds) and their use for making polymerizable compositions which after polymerization give optically transparent articles, such as ophthalmic lenses, having improved mechanical and optical properties and in particular having an improved UV cut.

  硫代磷化合物（也称为磷硫化合物），及其用于制备可聚合的组合物，聚合后形成光学透明的制品，例如具有改善机械和光学性能，特别是具有改善紫外线切除的眼科镜片。
• Photopolymerizable composition and use thereof
  申请人：Imai Masao

  公开号：US20060003261A1

  公开（公告）日：2006-01-05

  A photopolymerizable composition comprising a polymerizable compound and a photopolymerization initiator, wherein the polymerizable compound is characterized by comprising (a) a bifunctional (meth)acrylic acid (thio)ester compound containing a sulfur atom in the molecule and (b) at least one of a (meth)acrylic acid ester compound represented by the general formula (1) or a bifunctional (meth)acrylic acid ester compound having a urethane linkage: wherein R 1 and R 2 are each independently a hydrogen atom or a methyl group; R 3 and R 4 are each independently an alkyl group, an aralkyl group, an aryl group or a halogen atom; m and n are each an integer of 0 to 2; X 1 is an alkylidene group having 1 to 3 carbon atoms; and Y 1 and Y 2 are each independently a poly(oxyalkylene) group with the proviso that at least one of Y 1 and Y 2 is a poly(oxyalkylene) group having a hydroxy group.

  一种光聚合物组合物，包括可聚合化合物和光聚合引发剂，其中可聚合化合物的特征在于包含(a)一种含有分子中硫原子的双官能基（甲基）丙烯酸（硫）酯化合物和(b)至少一种由通式（1）表示的（甲基）丙烯酸酯化合物或具有脲链的双官能基（甲基）丙烯酸酯化合物：其中R1和R2各自独立地表示氢原子或甲基基团；R3和R4各自独立地表示烷基基团、芳基烷基基团、芳基基团或卤素原子；m和n各自为0到2的整数；X1表示具有1到3个碳原子的烷基亚基团；Y1和Y2各自独立地表示聚（氧烷基）基团，但至少其中之一为具有羟基的聚（氧烷基）基团。
• THIOPHOSPHINE COMPOUNDS AND METHODS OF MAKING POLYMERIZABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTHALMIC LENSES
  申请人：Wanigatunga Sirisoma

  公开号：US20070232834A1

  公开（公告）日：2007-10-04

  Thiophosphine compounds (also named phosphine sulfide compounds) and their use for making polymerizable compositions which after polymerization give optically transparent articles, such as ophthalmic lenses, having improved mechanical and optical properties and in particular having an improved UV cut.

  硫代膦化合物（也称为膦硫化合物）及其用于制备可聚合组合物的方法，聚合后得到具有改善机械和光学性能，特别是具有改善紫外线切割性能的光学透明物品，例如眼镜镜片。