1-[2-(2-Pentylsulfanyl-ethoxy)-ethylsulfanyl]-pentane | 149792-06-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-(2-Pentylsulfanyl-ethoxy)-ethylsulfanyl]-pentane
• 英文别名: 1-[2-(2-Pentylsulfanylethoxy)ethylsulfanyl]pentane
• CAS: 149792-06-3
• 化学式: C₁₄H₃₀OS₂
• 分子量: 278.524
• InChiKey: JOAHJYXPSSRUHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  59.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-羟基乙基戊基硫化物 以84%的产率得到
  参考文献：
  名称：

  GADZHIEV, M. K., XIMIYA I XIM. TEXNOL., TBILISI,(1988) S. 297-300

  摘要：

  DOI：

文献信息

• TUMOR-TARGETING EVALUATION METHODOLOGY AND COMPOUNDS RELATED THERETO
  申请人：GOURDEAU Henriette

  公开号：US20090062255A1

  公开（公告）日：2009-03-05

  The invention relates to a method for evaluating a chemotherapeutic potential of a candidate molecule. In evaluating the candidate molecule, the candidate molecule is tested for its ability to inhibit the in vitro growth of a cancer cell; to bind a cellular receptor produced by a cancer cell, wherein said receptor, such as a peripheral benzodiazepine receptor, is produced in a greater amount by said cancer cell than by a normal cell; and to inhibit the activity of at least one protein member of the MAPK pathway. The invention further relates to dibenzodiazepinone analogues and derivatives thereof.

  该发明涉及一种评估候选分子化疗潜力的方法。在评估候选分子时，将测试候选分子抑制癌细胞体外生长的能力；结合由癌细胞产生的细胞受体，其中所述受体，如外周苯二氮卓受体，由所述癌细胞产生的数量比正常细胞多；并抑制MAPK通路中至少一个蛋白质成员的活性。该发明还涉及二苯二氮卓酮类似物及其衍生物。
• Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals
  申请人：McAlpine B. James

  公开号：US20060079509A1

  公开（公告）日：2006-04-13

  The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.

  本发明涉及由式 I 表示的具有生物活性的二苯并二氮杂卓类似物、生产它们的方法、包含它们的药物组合物以及治疗肿瘤疾病的方法。
• Polycyclic aromatics and derivatives thereof and processes for their preparation
  申请人：McAlpine B. James

  公开号：US20060106028A1

  公开（公告）日：2006-05-18

  This invention relates to novel biologically active polycyclic aromatics produced by cultivation of Micromonospora echinospora ssp. challisensis NRRL 12255. The invention also relates to their pharmaceutically acceptable salts, prodrugs and derivatives, and to methods of obtaining them by post-biosynthesis chemical modification. The invention further relates to the use of the polycyclic aromatics and their derivatives in the preparation of medicaments for the treatment of neoplastic conditions and bacterial infections.

  本发明涉及新型生物活性多环芳烃，通过培养 小单胞菌 ssp. 菌株产生的新型生物活性多环芳烃。 NRRL 12255。本发明还涉及它们的药学上可接受的盐、原药和衍生物，以及通过生物合成后化学修饰获得它们的方法。本发明还涉及多环芳烃及其衍生物在制备治疗肿瘤和细菌感染的药物中的用途。
• TRANSITION METAL COMPLEXES CONTAINING SULFUR LIGANDS, AND POLYOLEFIN PRODUCTION PROCESSES USING THEM
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP1328558A2

  公开（公告）日：2003-07-23
• DIBENZODIAZEPINONE ANALOGUES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS
  申请人：Ecopia Biosciences Inc.

  公开号：EP1809612A1

  公开（公告）日：2007-07-25