r-1,t-2-amino-t-6-methylcyclohexanol | 139894-07-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: r-1,t-2-amino-t-6-methylcyclohexanol
• 英文别名: (1R,2R,6S)-2-amino-6-methylcyclohexan-1-ol
• CAS: 139894-07-8；139894-08-9；139894-09-0
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: DJCMRYQHJCVBKZ-RRKCRQDMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲基-2-环己烯-1-胺 生成 r-1,t-2-amino-t-6-methylcyclohexanol
  参考文献：
  名称：

  Przewoska-Ratajczak, Krystyna; Uzarewicz, Arkadiusz, Polish Journal of Chemistry, 1991, vol. 65, # 5-6, p. 945 - 958

  摘要：

  DOI：

文献信息

• SULFONAMIDES DERIVED FROM TRICYCLYL-2-AMINOCYCLOALKANOLS AS ANTICANCER AGENTS
  申请人：ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

  公开号：US20170015625A1

  公开（公告）日：2017-01-19

  A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus: The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.
• US9937186B2
  申请人：——

  公开号：US9937186B2

  公开（公告）日：2018-04-10