N-tert-butyl-C-[2-(pyridin-2-yloxy)ethyl]nitrone | 850536-82-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-tert-butyl-C-[2-(pyridin-2-yloxy)ethyl]nitrone
• 英文别名: N-tert-butyl-3-pyridin-2-yloxypropan-1-imine oxide
• CAS: 850536-82-2
• 化学式: C₁₂H₁₈N₂O₂
• 分子量: 222.287
• InChiKey: JODDYTOVFMHVPK-ZROIWOOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  50.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Nitrone compounds, prodrugs and pharmaceuticals compositons of the same to treat human disorders
  申请人：Kelly G. Michael

  公开号：US20050192281A1

  公开（公告）日：2005-09-01

  Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.

  本发明揭示了芳香族、杂芳香族和双环芳基亚硝基化合物以及含有这些衍生物的药物组合物。所揭示的组合物对于预防和/或治疗哺乳动物的疼痛、神经退行性、自身免疫和炎症性疾病或状况具有有用性。
• NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS
  申请人：Renovis, Inc.

  公开号：EP1677745A2

  公开（公告）日：2006-07-12
• EP1677745A4
  申请人：——

  公开号：EP1677745A4

  公开（公告）日：2008-10-22
• [EN] NITRONE COMPOUNDS PRODRUGS AND PHARMACEUTICAL COMPOSITIONS OF THE SAME TO TREAT HUMAN DISORDERS<br/>[FR] PROMEDICAMENTS A BASE DE COMPOSES NITRONES, ET COMPOSITIONS PHARMACEUTIQUES CORRESPONDANTES PERMETTANT DE TRAITER DES TROUBLES CHEZ L'HOMME
  申请人：RENOVIS INC

  公开号：WO2005037208A2

  公开（公告）日：2005-04-28

  Disclosed are aryl, heteroaromatic and bicyclic aryl nitrone compounds and pharmaceutical compositions containing such derivatives. The disclosed compositions are useful for preventing and/or treating pain, neurodegenerative, autoimmune and inflammatory diseases or conditions in mammals.