2-(2-Ethenyl-3-methoxyphenyl)cyclobutan-1-one | 197015-38-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(2-Ethenyl-3-methoxyphenyl)cyclobutan-1-one
• CAS: 197015-38-6
• 化学式: C₁₃H₁₄O₂
• 分子量: 202.253
• InChiKey: LUOAEFMBENIRLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  异丙烯基溴化镁 、 2-(2-Ethenyl-3-methoxyphenyl)cyclobutan-1-one 在 cerium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 以83%的产率得到
  参考文献：
  名称：

  A Novel Palladium-Mediated Cascade Reaction Triggered by Strain Release of the Cyclobutane System. A New General Route to Benzo- and Naphthohydrindans

  摘要：

  A novel palladium-mediated cascade reaction was reported. By this procedure, the olefinic cyclobutanols 17, 24, and 31; 41; 37; and 45 afforded the benzo-and naphthohydrindans (46-49, 50-53, 54-57, and 58-61) respectively in one operation in the ratios depending on the mediators and solvents employed. This provides a novel and efficient synthesis of biologically important A-nor and C-11-alkylated steroids.

  DOI：

  10.1021/jo971377z
• 作为产物：
  描述：

  (2-甲酰基-6-甲氧基苯基)三氟甲磺酸酯 在 tetrafluoroboric acid 、 四(三苯基膦)钯 、 sodium hydride 、 间氯过氧苯甲酸 、 lithium chloride 作用下， 以 四氢呋喃 为溶剂， 生成 2-(2-Ethenyl-3-methoxyphenyl)cyclobutan-1-one
  参考文献：
  名称：

  A Novel Palladium-Mediated Cascade Reaction Triggered by Strain Release of the Cyclobutane System. A New General Route to Benzo- and Naphthohydrindans

  摘要：

  A novel palladium-mediated cascade reaction was reported. By this procedure, the olefinic cyclobutanols 17, 24, and 31; 41; 37; and 45 afforded the benzo-and naphthohydrindans (46-49, 50-53, 54-57, and 58-61) respectively in one operation in the ratios depending on the mediators and solvents employed. This provides a novel and efficient synthesis of biologically important A-nor and C-11-alkylated steroids.

  DOI：

  10.1021/jo971377z

文献信息

• A Novel Palladium-Mediated Cascade Reaction Triggered by Strain Release of the Cyclobutane System. A New General Route to Benzo- and Naphthohydrindans
  作者：Hideo Nemoto、Junji Miyata、Masahiro Yoshida、Naomi Raku、Keiichiro Fukumoto

  DOI：10.1021/jo971377z

  日期：1997.10.1

  A novel palladium-mediated cascade reaction was reported. By this procedure, the olefinic cyclobutanols 17, 24, and 31; 41; 37; and 45 afforded the benzo-and naphthohydrindans (46-49, 50-53, 54-57, and 58-61) respectively in one operation in the ratios depending on the mediators and solvents employed. This provides a novel and efficient synthesis of biologically important A-nor and C-11-alkylated steroids.