D-Mannitol, mixt. with 1,2,3-propanetriol | 77621-88-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Mannitol, mixt. with 1,2,3-propanetriol
• 英文别名: (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol;propane-1,2,3-triol
• CAS: 77621-88-6
• 化学式: C9H22O9
• 分子量: 274.27
• InChiKey: ZKIRNCACNZXACZ-MVNLRXSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.25
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  182
• 氢给体数：
  9
• 氢受体数：
  9

文献信息

• SPECIALLY FORMULATED COMPOSITIONS OF INHALED NINTEDANIB AND NINTEDANIB SALTS
  申请人：Avalyn Pharma Inc.

  公开号：US20200060968A1

  公开（公告）日：2020-02-27

  Disclosed herein are formulations of nintedanib and salts thereof, indolinone derivative compounds and salts thereof for aerosolization and use of such formulations for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. Formulations and delivery options described herein allow for efficacious local delivery of nintedanib or a indolinone derivative compound or salt thereof. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that benefit by reformulation and inhalation administration.

  本文公开了尼特丹尼布及其盐、吲哚酮衍生物化合物及其盐的配方，用于喷雾剂，并使用这些配方预防或治疗各种纤维化、致癌、血管和病毒感染性疾病，包括与肺部、心脏、肾脏、肝脏、眼睛、中枢神经系统和手术部位相关的疾病。本文所描述的配方和传递选项允许有效地局部传递尼特丹尼布或吲哚酮衍生物化合物或其盐。方法包括吸入程序、适应症和制造过程，用于生产和使用所述的组合物。还包括识别通过重新配制和吸入给药获益的化合物和适应症的方法。
• Compositions comprising cationic polysaccharides and cationic drugs
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0888770A1

  公开（公告）日：1999-01-07

  The present invention relates to delivery systems comprising a cationic polymer, optionally in conjunction with an anionic polymer, to deliver cationic therapeutic agents and their application to a mucosal surface. In particular, these delivery systems are well suited for the treatment of intraocular pressure and glaucoma by way of a sustained delivery system.

  本发明涉及一种传递系统，包括阳离子聚合物，可选地与阴离子聚合物结合，用于传递阳离子治疗剂，并应用于黏膜表面。特别是，这些传递系统非常适用于通过持续传递系统治疗眼压和青光眼。
• Heteropolysaccharide and its Production and use
  申请人：Merck & Co., Inc.

  公开号：EP0211506A1

  公开（公告）日：1987-02-25

  Heteropolysaccharide S-184 is a new heteropolysaccharide. It is composed principally of carbohydrate, from 12% to 16% protein and from 3.0% to 4.5% (calculated as acetic acid) acyl groups, the carbohydrate portion containing from about 7% to 16% uronic acid and the neutral sugars mannose, glucose and galactose in the approximate molar ratios of 1:3:5. It can be prepared by fermentation of a newAlcaligenes species, ATCC 53160. It has valuable properties as a thickening, suspending and stabilizing agent in aqueous solutions and is especially valuable for use in foods.

  杂多糖 S-184 是一种新型杂多糖。它主要由碳水化合物、12% 至 16% 的蛋白质和 3.0% 至 4.5%（以乙酸计算）的酰基组成，碳水化合物部分含有约 7% 至 16% 的尿酸和中性糖甘露糖、葡萄糖和半乳糖，摩尔比约为 1:3:5。它可以通过一种新的 Alcaligenes 菌种（ATCC 53160）发酵制备。它具有在水溶液中作为增稠剂、悬浮剂和稳定剂的重要特性，尤其适用于食品。
• Pharmaceutical composition for the treatment of cerebral edema
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0369474A2

  公开（公告）日：1990-05-23

  A pharmaceutical composition and its use in the treatment of cerebral edema are provided wherein the composition comprises an atrial natriuretic peptide having an amino acid sequence of 28 amino acids and at least one pharmaceutically acceptable carrier, diluent or excipient.

  提供了一种药物组合物及其在治疗脑水肿中的用途，其中该组合物包含具有 28 个氨基酸序列的心房利钠肽和至少一种药学上可接受的载体、稀释剂或赋形剂。
• PROCESS FOR PREPARING (1-3)-BETA-D-GLUCAN FROM FUNGI
  申请人：Seikagaku Corporation

  公开号：EP1024147A1

  公开（公告）日：2000-08-02

  The present invention relates to a process for preparing (1→3)-β-D-glucan, comprising subjecting a fungal cell to oxidation degradation under alkaline conditions to release (1→3)-β-D-glucan from a cell wall of the cell. (1→3)-β-D-Glucan can be prepared easily and efficiently from a cell of a microorganism belonging to the genus Candida. An accurate measurement process having a high reproducibility of (1→3)-β-D-glucan can be provided by using the above-described glucan or stabilized glucan into a kit and using it as a standard substance, and a large amount of the (1→3)-β-D-glucan having various biological activities can be solubilized and purified from a fungus, such as Candida or the like.

  本发明涉及一种制备(1→3)-β-D-葡聚糖的工艺，包括在碱性条件下对真菌细胞进行氧化降解，以从细胞的细胞壁中释放出(1→3)-β-D-葡聚糖。(1→3)-β-D-葡聚糖可以从属于白色念珠菌属的微生物细胞中轻松高效地制备出来。通过将上述葡聚糖或稳定葡聚糖制成试剂盒并将其用作标准物质，可提供具有较高重现性的（1→3）-β-D-葡聚糖的精确测量过程，并可从念珠菌等真菌中溶解和纯化大量具有各种生物活性的（1→3）-β-D-葡聚糖。