4-(benzyloxy)-N-[(1R,2S)-1-[[(3R)-6-chloro-3-[(dimethylamino)methyl]-3,4-dihydro-1(2H)-quinolinyl]carbonyl]-2-(1H-indol-3-yl)propyl]-1-piperidinecarboxamide | 528861-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(benzyloxy)-N-[(1R,2S)-1-[[(3R)-6-chloro-3-[(dimethylamino)methyl]-3,4-dihydro-1(2H)-quinolinyl]carbonyl]-2-(1H-indol-3-yl)propyl]-1-piperidinecarboxamide
• 英文别名: N-[(2R,3S)-1-[(3R)-6-chloro-3-[(dimethylamino)methyl]-3,4-dihydro-2H-quinolin-1-yl]-3-(1H-indol-3-yl)-1-oxobutan-2-yl]-4-phenylmethoxypiperidine-1-carboxamide
• CAS: 528861-22-5
• 化学式: C₃₇H₄₄ClN₅O₃
• 分子量: 642.241
• InChiKey: NSKIZGLUWXOPJC-HUMJLNPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  46
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  80.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Amine derivative
  申请人：Abe Hidenori

  公开号：US20050245571A1

  公开（公告）日：2005-11-03

  The present invention provide a compound of the formula: wherein X and X′ are the same or different and each represents a hydrogen atom, etc.; R 1 and R 2 are the same or different and each represents a hydrogen atom, etc.; R 3 represents a hydrocarbon group optionally having substituents, etc.; R 4 represents a hydrogen atom, etc.; Y and Ya are the same or different and each represents a bond or a spacer having a main chain of 1 to 8 atoms; Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibitory activity and is useful for preventing and/or treating diseases associated with somatostatin.

  本发明提供一种化合物，其式为：其中X和X′相同或不同，每个代表氢原子等；R1和R2相同或不同，每个代表氢原子等；R3表示一个烃基，可选地具有取代基等；R4表示氢原子等；Y和Ya相同或不同，每个代表键或具有1至8个原子的主链的间隔物；Z和Za相同或不同，每个代表氢原子等；或其盐或前药，具有生长抑素受体结合抑制活性，并用于预防和/或治疗与生长抑素相关的疾病。
• AMINE DERIVATIVE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1437351A1

  公开（公告）日：2004-07-14

  The present invention provide a compound of the formula: wherein X and X' are the same or different and each represents a hydrogen atom, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrocarbon group optionally having substituents, etc.; R4 represents a hydrogen atom, etc.; Y and Ya are the same or different and each represents a bond or a spacer having a main chain of 1 to 8 atoms; Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibitory activity and is useful for preventing and/or treating diseases associated with somatostatin.

  本发明提供一种式的化合物： 其中X和X'相同或不同，各自代表氢原子等；R1和R2相同或不同，各自代表氢原子等；R3代表任选具有取代基的烃基等；R4代表氢原子等。Y和Ya相同或不同，各自代表键或具有1至8个原子的主链的间隔物；Z和Za相同或不同，各自代表氢原子等；或其盐或其原药，具有抑制体生长抑素受体结合的活性，可用于预防和/或治疗与体生长抑素相关的疾病。