Methyl-curcumol | 4905-52-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl-curcumol
• 英文别名: Curcumol-methylaether；8-Methoxy-2-methyl-6-methylidene-9-propan-2-yl-11-oxatricyclo[6.2.1.01,5]undecane
• CAS: 4905-52-6
• 化学式: C₁₆H₂₆O₂
• 分子量: 250.381
• InChiKey: MSXQFHGVJPYWFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Curcumol derivatives, the compositions containing the said derivatives, and the use of the same in the manufacture of medicaments
  申请人：Wang Shulong

  公开号：US20070191360A1

  公开（公告）日：2007-08-16

  The present invention provides curcumol derivatives of the following formula (I) or pharmaceutical acceptable salts thereof: wherein, Y is selected from the group consisting of ═CHR 2 , —CH 2 R 2 , ═O, —OH or —OR 1 ;R 1 is selected from H, R, RCO or HO 3 S; and R is selected from the group consisting of H; saturated or unsaturated linear C 1-10 hydrocarbon group and the like; R 2 is selected from the group consisting of F; Cl; Br; I; H; —OH; —OR; —HSO 3 and the like; with the proviso that both R 1 and R 2 are not H. The present invention also provides anti-tumor or antiviral pharmaceutical compositions comprising said derivatives or pharmaceutical acceptable salts thereof. The present invention further provides the use of said derivatives or pharmeceutical acceptable salts thereof in the preparation of a medicament for prophylaxis and/or treatment tumor or an antiviral medicament.

  本发明提供以下式（I）的姜黄醇衍生物或其药学上可接受的盐：其中，Y选自 ═CHR2，—CH2R2，═O，—OH或—OR1的群组；R1选自H，R，RCO或HO3S；R选自H；饱和或不饱和的线性C1-10烃基等群组；R2选自F，Cl，Br，I，H，—OH，—OR，—HSO3等群组；但要求R1和R2均不为H。本发明还提供包含上述衍生物或其药学上可接受的盐的抗肿瘤或抗病毒药物组合物。本发明还提供使用上述衍生物或其药学上可接受的盐制备预防和/或治疗肿瘤或抗病毒药物的药物。
• US7700584B2
  申请人：——

  公开号：US7700584B2

  公开（公告）日：2010-04-20