[2-(4-chloro-2-methoxy-phenoxy)-3-methoxy-6-methyl-pyridin-4-yl]-(1-methoxymethyl-propyl)-amine | 351379-45-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2-(4-chloro-2-methoxy-phenoxy)-3-methoxy-6-methyl-pyridin-4-yl]-(1-methoxymethyl-propyl)-amine
• 英文别名: 2-(4-chloro-2-methoxyphenoxy)-3-methoxy-N-(1-methoxybutan-2-yl)-6-methylpyridin-4-amine
• CAS: 351379-45-8
• 化学式: C₁₉H₂₅ClN₂O₄
• 分子量: 380.871
• InChiKey: DDHXAVJLUNGILS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Corticotropin releasing factor antagonists
  申请人：——

  公开号：US20020016328A1

  公开（公告）日：2002-02-07

  Corticotropin-releasing factor (CRF) antagonists having the formulae 1 wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.

  具有以下公式的促肾上腺皮质激素释放因子（CRF）拮抗剂，其中虚线、A、B、Y、Z、G、R3、R4、R5、R6、R16和R17如申请中所定义，并且制备它们的过程。这些化合物及其药用盐可用于治疗包括中枢神经系统和与压力相关的疾病。
• CORTICOTROPIN RELEASING FACTOR ANTAGONISTS
  申请人：Pfizer Products Inc.

  公开号：EP1263732A1

  公开（公告）日：2002-12-11
• IMPROVED BUFFER GEL FOR IONTOPHORESIS ELECTRODES
  申请人：Plummer Thomas

  公开号：US20050197618A1

  公开（公告）日：2005-09-08

  An iontophoretic delivery device utilizing a polymeric gel matrix to ameliorate pH deviation within the device wherein the pH of the polymeric gel matrix is buffered at select pH ranges in order to reduce skin irritation. The polymeric gel matrix is housed within the iontophoretic delivery device as a buffering agent wherein the matrix provides a suitable physiological pH level above 4.0 and particularly the pH level deviates between approximately 4.1 to approximately 4.9, and preferably at the pH 4.5 for an effective operation of the iontophoretic delivery of a medicament to treat affected areas of a living subject's body.
• US6833378B2
  申请人：——

  公开号：US6833378B2

  公开（公告）日：2004-12-21
• US6844351B1
  申请人：——

  公开号：US6844351B1

  公开（公告）日：2005-01-18