(2S)-2-[[(2R,3S,4R,5S)-5-[(2R,3S,4S)-5-[4-[[(1R)-1-(2-氨基-7-甲基-4-氧代-1H-蝶啶-6-基)乙基]氨基]苯基]-2,3,4-三羟基戊氧基]-3,4-二羟基四氢呋喃-2-基]甲氧基-羟基磷酰]氧基戊二酸 | 79484-89-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2S)-2-[[(2R,3S,4R,5S)-5-[(2R,3S,4S)-5-[4-[[(1R)-1-(2-氨基-7-甲基-4-氧代-1H-蝶啶-6-基)乙基]氨基]苯基]-2,3,4-三羟基戊氧基]-3,4-二羟基四氢呋喃-2-基]甲氧基-羟基磷酰]氧基戊二酸
• 英文名称: Methanopterin
• 英文别名: (2S)-2-[[(2R,3S,4R,5S)-5-[(2R,3S,4S)-5-[4-[[(1R)-1-(2-amino-7-methyl-4-oxo-3H-pteridin-6-yl)ethyl]amino]phenyl]-2,3,4-trihydroxypentoxy]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxypentanedioic acid
• CAS: 79484-89-2
• 化学式: C₃₀H₄₁N₆O₁₆P
• 分子量: 772.7
• InChiKey: ZHAHWVAVMXKKOA-NKRFXTRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  53
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  354
• 氢给体数：
  11
• 氢受体数：
  18

文献信息

• Designer Calvin-Cycle-Channeled and Hydrogenotrophic Production of Butanol and Related Higher Alcohols
  申请人：Lee James Weifu

  公开号：US20130344553A1

  公开（公告）日：2013-12-26

  Designer Calvin-cycle-channeled and hydrogenotrophic biofuel-production pathways, the associated designer genes and designer transgenic organisms for autotrophic production of butanol and related higher alcohols from carbon dioxide, hydrogen, and/or water are provided. The butanol and related higher alcohols include 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer autotrophic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and hydrogenotrophic pathway gene(s) and biosafety-guarding technology for enhanced autotrophic production of butanol and related higher alcohols from carbon dioxide and water.

  本发明提供了设计师Calvin循环通道和氢营养生物燃料生产途径，以及相关的设计师基因和设计师转基因生物，用于从二氧化碳、氢和/或水的自养生产丁醇和相关的高级醇。丁醇和相关的高级醇包括1-丁醇、2-甲基-1-丁醇、异丁醇、3-甲基-1-丁醇、1-己醇、1-辛醇、1-戊醇、1-庚醇、3-甲基-1-戊醇、4-甲基-1-己醇、5-甲基-1-庚醇、4-甲基-1-戊醇、5-甲基-1-己醇和6-甲基-1-庚醇。设计师自养生物，例如设计师转基因光合细菌和藻类，包括设计师Calvin循环通道和氢营养途径基因和生物安全保护技术，以增强从二氧化碳和水中自养生产丁醇和相关高级醇的能力。
• Designer Photoautotrophic and Hydrogenotrophic Production of Alcohols and Biodiesel
  申请人：Lee James Weifu

  公开号：US20150353961A1

  公开（公告）日：2015-12-10

  Designer Calvin-cycle-channeled and hydrogenotrophic biofuel-production pathways, the associated designer genes and designer transgenic organisms for autotrophic production of alcohols and biodiesel from carbon dioxide, hydrogen, and/or water are disclosed. The alcohols include methanol, ethanol, propanol, 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer autotrophic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and hydrogenotrophic pathway gene(s) and biosafety-guarding technology for enhanced autotrophic production of alcohols and biodiesel from carbon dioxide and water; wherein the designer transgenic cells in their mass liquid culture can inducibly self-flocculate for enhanced harvesting of their biomass upon the expression of the designer cell surface-linked positively charged polypeptides.

  公开了设计师卡尔文循环通道和氢营养生物燃料生产途径，相关的设计师基因和设计师转基因生物，用于自养生产醇类和生物柴油，从二氧化碳、氢和/或水中获取。醇类包括甲醇、乙醇、丙醇、1-丁醇、2-甲基-1-丁醇、异丁醇、3-甲基-1-丁醇、1-己醇、1-辛醇、1-戊醇、1-庚醇、3-甲基-1-戊醇、4-甲基-1-己醇、5-甲基-1-庚醇、4-甲基-1-戊醇、5-甲基-1-己醇和6-甲基-1-庚醇。设计师自养生物如设计师转基因氧合光合细菌和藻类包括设计师卡尔文循环通道和氢营养途径基因和生物安全保护技术，以增强从二氧化碳和水中自养生产醇类和生物柴油的能力。其中，设计师转基因细胞在其质量液体培养中可诱导自我絮凝，以增强表达设计师细胞表面连接的带正电的多肽后，收获其生物量。
• Obesity small molecules
  申请人：Akron Molecules GmbH

  公开号：EP2633884A1

  公开（公告）日：2013-09-04

  The present invention relates to new therapies to treat obesity and related diseases, as well as for reducing triglyceride levels and body weight.

  本发明涉及治疗肥胖症和相关疾病以及降低甘油三酯水平和体重的新疗法。
• METHANOTHERMOBACTER THERMAUTOTROPHICUS STRAIN AND VARIANTS THEREOF
  申请人：The University of Chicago

  公开号：EP3072979A1

  公开（公告）日：2016-09-28

  Provided herein is an isolated Methanothermobacter microorganism that is (a) a microorganism of Methanothermobacter thermautotrophicus strain UC 120910, deposited on December 21, 2010, with the American Type Culture Collection (ATCC) under ATCC® Patent Deposit Designation No. PTA-11561, (b) a variant of the microorganism of Methanothermobacter thermautotrophicus strain UC 120910, or (c) a progeny of the microorganism of Methanothermobacter thermautotrophicus strain UC 120910, wherein the variant or progeny retains the phenotypic characteristics of the microorganism of Methanothermobacter thermautotrophicus strain UC 120910. Also provided herein is a substantially pure culture or monoculture comprising the Methanothermobacter microorganism of the disclosure. A system for converting electric power into methane, comprising a biological reactor having at least a cathode, an anode, a presently disclosed Methanothermobacter microorganism, water, and carbon dioxide, and method of using the system for converting electricity into methane are further provided herein.

  本文提供了一种分离的 Methanothermobacter 微生物，该微生物是 (a) Methanothermobacter thermautotrophicus 菌株 UC 120910 的微生物，该菌株于 2010 年 12 月 21 日以 ATCC® Patent Deposit Designation No.PTA-11561 的美国模式培养物保藏中心 (ATCC)，(b) 热自养甲烷杆菌菌株 UC 120910 微生物的变种，或 (c) 热自养甲烷杆菌菌株 UC 120910 微生物的后代，其中变种或后代保留了热自养甲烷杆菌菌株 UC 120910 微生物的表型特征。本文还提供了一种包含本公开的甲烷热菌微生物的基本纯培养物或单一培养物。本文还提供了一种将电力转化为甲烷的系统，该系统包括一个生物反应器，该反应器至少具有一个阴极、一个阳极、一种本公开的甲烷热杆菌微生物、水和二氧化碳，以及使用该系统将电力转化为甲烷的方法。
• DESIGNER PHOTOAUTOTROPHIC AND HYDROGENOTROPHIC PRODUCTION OF ALCOHOLS AND BIODIESEL
  申请人：Lee, James Weifu

  公开号：EP3133163A1

  公开（公告）日：2017-02-22

  Designer Calvin-cycle-channeled and hydrogenotrophic biofuel-production pathways, the associated designer genes and designer transgenic organisms for autotrophic production of alcohols and biodiesel from carbon dioxide, hydrogen, and/or water are disclosed. The alcohols include methanol, ethanol, propanol, 1-butanol, 2-methyl-1-butanol, isobutanol, 3-methyl-1-butanol, 1-hexanol, 1-octanol, 1-pentanol, 1-heptanol, 3-methyl-1-pentanol, 4-methyl-1-hexanol, 5-methyl-1-heptanol, 4-methyl-1-pentanol, 5-methyl-1-hexanol, and 6-methyl-1-heptanol. The designer autotrophic organisms such as designer transgenic oxyphotobacteria and algae comprise designer Calvin-cycle-channeled and hydrogenotrophic pathway gene(s) and biosafety-guarding technology for enhanced autotrophic production of alcohols and biodiesel from carbon dioxide and water; wherein the designer transgenic cells in their mass liquid culture can inducibly self-flocculate for enhanced harvesting of their biomass upon the expression of the designer cell surface-linked positively charged polypeptides.

  本发明公开了利用二氧化碳、氢气和/或水自养生产醇类和生物柴油的设计卡尔文循环通道和氢自养生物燃料生产途径、相关设计基因和设计转基因生物。醇类包括甲醇、乙醇、丙醇、1-丁醇、2-甲基-1-丁醇、异丁醇、3-甲基-1-丁醇、1-己醇、1-辛醇、1-戊醇、1-庚醇、3-甲基-1-戊醇、4-甲基-1-己醇、5-甲基-1-庚醇、4-甲基-1-戊醇、5-甲基-1-己醇和 6-甲基-1-庚醇。设计的自养生物，如设计的转基因氧光合细菌和藻类，包括设计的卡尔文循环通道和氢营养途径基因和生物安全防护技术，用于提高利用二氧化碳和水自养生产酒精和生物柴油的能力；其中设计的转基因细胞在其大量液体培养中，在表达设计的细胞表面连接的带正电荷的多肽时，可诱导自絮凝，以提高其生物量的收获。