5-O-Acrylguanosin | 34625-05-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 5-O-Acrylguanosin
• 英文别名: O^5'-acryloyl-guanosine；[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl prop-2-enoate
• CAS: 34625-05-3
• 化学式: C₁₃H₁₅N₅O₆
• 分子量: 337.292
• InChiKey: GPUGVAJVAFQYGR-JJNLEZRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Controlled drug delivery system using the conjugation of drug to biodegradable polyester
  申请人：——

  公开号：US20040013728A1

  公开（公告）日：2004-01-22

  The present invention relates to the molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect. Moreover, the high loading efficiency of hydrophilic drugs can be achieved.

  本发明涉及通过共价键将待释放的分子与可生物降解聚酯聚合物结合而构建的分子持续控释系统，以及其制备方法。根据本发明，该系统可以制备成微球、纳米颗粒或薄膜。上述系统中的分子释放速率可以调节为与可生物降解聚酯聚合物的化学降解速率成比例，从而导致释放近似零级动力学剖面而不显示爆发效应。此外，可以实现亲水药物的高装载效率。
• Preparations of poly(lactic-co-glycolic acid)/polydopamine core/shell hybrid nanoparticle for photothermal applications
  申请人：UNIVERSITY OF SOUTH CAROLINA

  公开号：US10835605B2

  公开（公告）日：2020-11-17

  Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal applications. The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. Optionally, the hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc. The nanoparticles can be useful for disease detection, treatment, and monitoring.

  描述了一种用于光热应用的可生物降解和生物相容的混合纳米粒子。这种混合纳米粒子包括一个聚乳酸-共聚乙醇酸核心和一个聚多巴胺外壳。可选地，混合纳米粒子可以装载活性剂，如抗癌剂。混合纳米粒子可包括检测剂、靶向剂等。这些纳米粒子可用于疾病检测、治疗和监测。
• PREPARATIONS OF POLY(LACTIC-CO-GLYCOLIC ACID)/POLYDOPAMINE CORE/SHELL HYBRID NANOPARITCLE FOR PHOTOTHERMAL APPLICATIONS
  申请人：UNIVERSITY OF SOUTH CAROLINA

  公开号：US20170095558A1

  公开（公告）日：2017-04-06

  Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal applications. The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. Optionally, the hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc. The nanoparticles can be useful for disease detection, treatment, and monitoring.
• US6589548B1
  申请人：——

  公开号：US6589548B1

  公开（公告）日：2003-07-08
• US7163698B2
  申请人：——

  公开号：US7163698B2

  公开（公告）日：2007-01-16