7-(4-biphenyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)lumazine | 170158-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-(4-biphenyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)lumazine
• CAS: 170158-02-8
• 化学式: C₃₉H₃₂N₄O₇
• 分子量: 668.706
• InChiKey: LZMPQPXUKHVDPN-WIHCDAFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  50.0
• 可旋转键数：
  8.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  142.47
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  7-(4-biphenyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)lumazine 在 sodium methylate 作用下， 以 吡啶 、 甲醇 为溶剂， 生成 7-(4-biphenyl)-1-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)lumazine
  参考文献：
  名称：

  Nucleosides, LVIII¹ Synthesis of Base - Modified Oligonucleotides Containing 6- and 7-Aryl Lumazines

  摘要：

  6-Phenyl-, 7-phenyl-, 6-(4-biphenyl)-7-(4-biphenyl)lumazine N-1-2-deoxy-beta-D-ribofuranosides were synthesized, then converted into the corresponding 5'-O-dimethoxytrityl-3'-O-(beta-cyanoethyl, N,N-diisopropyl)phosphoramidites and incorporated into different positions of self-complementary oligonucleotides. The influence of modifications on the melting temperature of the resulting duplexes was studied.

  DOI：

  10.1080/07328319608002396
• 作为产物：
  描述：

  4-联苯基乙二醛 在 六甲基二硅氮烷 、 zinc(II) chloride 、 氯甲基三甲基硅烷 作用下， 以 ammonium hydroxide 、 乙醇 为溶剂， 反应 2.0h， 生成 7-(4-biphenyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-ribofuranosyl)lumazine
  参考文献：
  名称：

  Nucleosides, LVIII¹ Synthesis of Base - Modified Oligonucleotides Containing 6- and 7-Aryl Lumazines

  摘要：

  6-Phenyl-, 7-phenyl-, 6-(4-biphenyl)-7-(4-biphenyl)lumazine N-1-2-deoxy-beta-D-ribofuranosides were synthesized, then converted into the corresponding 5'-O-dimethoxytrityl-3'-O-(beta-cyanoethyl, N,N-diisopropyl)phosphoramidites and incorporated into different positions of self-complementary oligonucleotides. The influence of modifications on the melting temperature of the resulting duplexes was studied.

  DOI：

  10.1080/07328319608002396