7-(4-biphenyl)-1-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)lumazine | 170158-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 7-(4-biphenyl)-1-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)lumazine
• 英文别名: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-7-(4-phenylphenyl)pteridine-2,4-dione
• CAS: 170158-18-6
• 化学式: C₄₄H₃₈N₄O₇
• 分子量: 734.808
• InChiKey: SKBUPOPFXMYEMM-LCKTVPPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.49
• 重原子数：
  55.0
• 可旋转键数：
  11.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  137.79
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  双(二异丙基氨基)(2-氰基乙氧基)膦 、 7-(4-biphenyl)-1-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)lumazine 在 四氮唑 作用下， 以 二氯甲烷 为溶剂， 以60%的产率得到7-(4-biphenyl)-1-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)lumazine-3'-O-(2-cyanoethyl,N,N-diisopropyl)phosphoramidite
  参考文献：
  名称：

  Nucleosides, LVIII¹ Synthesis of Base - Modified Oligonucleotides Containing 6- and 7-Aryl Lumazines

  摘要：

  6-Phenyl-, 7-phenyl-, 6-(4-biphenyl)-7-(4-biphenyl)lumazine N-1-2-deoxy-beta-D-ribofuranosides were synthesized, then converted into the corresponding 5'-O-dimethoxytrityl-3'-O-(beta-cyanoethyl, N,N-diisopropyl)phosphoramidites and incorporated into different positions of self-complementary oligonucleotides. The influence of modifications on the melting temperature of the resulting duplexes was studied.

  DOI：

  10.1080/07328319608002396
• 作为产物：
  描述：

  7-(4-biphenyl)lumazine 在 sodium methylate 、 六甲基二硅氮烷 、 zinc(II) chloride 、 氯甲基三甲基硅烷 作用下， 以 吡啶 、 甲醇 为溶剂， 生成 7-(4-biphenyl)-1-(2-deoxy-5-O-dimethoxytrityl-β-D-ribofuranosyl)lumazine
  参考文献：
  名称：

  Nucleosides, LVIII¹ Synthesis of Base - Modified Oligonucleotides Containing 6- and 7-Aryl Lumazines

  摘要：

  6-Phenyl-, 7-phenyl-, 6-(4-biphenyl)-7-(4-biphenyl)lumazine N-1-2-deoxy-beta-D-ribofuranosides were synthesized, then converted into the corresponding 5'-O-dimethoxytrityl-3'-O-(beta-cyanoethyl, N,N-diisopropyl)phosphoramidites and incorporated into different positions of self-complementary oligonucleotides. The influence of modifications on the melting temperature of the resulting duplexes was studied.

  DOI：

  10.1080/07328319608002396

文献信息

• Synthesis of Base-Modified Oligonucleotides Containing 6- and 7-Aryl Lumazines
  作者：Yuris Maurinsh、Wolfgang Pfleiderer

  DOI：10.1080/15257779508012473

  日期：1995.5.1