4,7-dichloro-3-hydroxy-3-(2-(4-hydroxyphenyl)-2-oxoethyl)indolin-2-one | 1037184-51-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,7-dichloro-3-hydroxy-3-(2-(4-hydroxyphenyl)-2-oxoethyl)indolin-2-one
• 英文别名: YK-4-289；4,7-dichloro-3-[2-(2,3,4-trichlorophenyl-2-oxoethyl)]-3-hydroxyl-1,3-dihydroindol-2-one；4,7-dichloro-3-hydroxy-3-[2-(4-hydroxyphenyl)-2-oxoethyl]-1H-indol-2-one
• CAS: 1037184-51-2
• 化学式: C₁₆H₁₁Cl₂NO₄
• 分子量: 352.174
• InChiKey: WNBJOKCPNXEIDK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS<br/>[FR] MÉTHODES ET COMPOSITIONS PERMETTANT DE TRAITER DES TUMEURS DE LA FAMILLE DU SARCOME D'EWING
  申请人：UNIV GEORGETOWN

  公开号：WO2013155341A1

  公开（公告）日：2013-10-17

  Compounds, compositions and methods relating to EWS-FLIl protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

  提供与EWS-FLIl蛋白抑制剂相关的化合物、组合物和方法。这些化合物在治疗包括Ewing肉瘤家族在内的癌症中具有用途。
• [EN] INDOLINONE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS D'INDOLINONE ET LEURS UTILISATIONS
  申请人：TOKALAS INC

  公开号：WO2016057698A1

  公开（公告）日：2016-04-14

  Indolinone derivative compounds that act as EWS-FLll transcription factor inhibitors are provided. Also provided are pharmaceutical compositions of the indolinone derivatives, methods of synthesizing the same, methods of treating using same, and assays for identifying the inhibitors of EWS-FLll oncoprotein.

  提供了作为EWS-FLll转录因子抑制剂的吲哚酮衍生物化合物。还提供了这些吲吲酮衍生物的药物组合物、合成方法、使用方法以及用于识别EWS-FLll致癌蛋白抑制剂的测定方法。
• INDOLINONE COMPOUNDS AND USES THEREOF
  申请人：Oncternal Therapeutics, Inc.

  公开号：EP3204376A1

  公开（公告）日：2017-08-16
• TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY
  申请人：Toretsky Jeffrey A.

  公开号：US20100004179A1

  公开（公告）日：2010-01-07

  Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.
• METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
  申请人：GEORGETOWN UNIVERSITY

  公开号：US20150051260A1

  公开（公告）日：2015-02-19

  Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.