1-bromo-2-(1-ethylethenyl)-4-methoxybenzene | 1214272-64-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-bromo-2-(1-ethylethenyl)-4-methoxybenzene
• CAS: 1214272-64-6
• 化学式: C₁₁H₁₃BrO
• 分子量: 241.128
• InChiKey: CKAJQCBVSDXYMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.88
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  二氧化碳 、 1-bromo-2-(1-ethylethenyl)-4-methoxybenzene 在 正丁基锂 、 盐酸 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 1.0h， 以56%的产率得到3-ethyl-5-methoxy-3-methyl-2-benzofuran-1(3H)-one
  参考文献：
  名称：

  New, Facile Synthesis of 3,3-Disubstituted Phthalides Based on the Reaction of α-Substituted 2-Lithiostyrenes with Carbon Dioxide

  摘要：

  A new method to prepare 3,3-disubstituted phthalides [isobenzofuran-1(3H)-ones] from alpha-substituted 2-bromostyrenes has been developed. The reaction of alpha-substituted 2-lithiostyrenes, generated in situ by bromine-lithium exchange between alpha-substituted 2-bromostyrenes and butyllithium, with carbon dioxide gave the corresponding lithium 2-vinylbenzoates, which upon treatment with concentrated hydrochloric acid afforded the desired products in one pot.

  DOI：

  10.3987/com-09-11837
• 作为产物：
  描述：

  1-(2-bromo-5-methoxyphenyl)-1-propanone 、 亚甲基三苯基膦烷 以 四氢呋喃 为溶剂， 以58%的产率得到1-bromo-2-(1-ethylethenyl)-4-methoxybenzene
  参考文献：
  名称：

  New, Facile Synthesis of 3,3-Disubstituted Phthalides Based on the Reaction of α-Substituted 2-Lithiostyrenes with Carbon Dioxide

  摘要：

  A new method to prepare 3,3-disubstituted phthalides [isobenzofuran-1(3H)-ones] from alpha-substituted 2-bromostyrenes has been developed. The reaction of alpha-substituted 2-lithiostyrenes, generated in situ by bromine-lithium exchange between alpha-substituted 2-bromostyrenes and butyllithium, with carbon dioxide gave the corresponding lithium 2-vinylbenzoates, which upon treatment with concentrated hydrochloric acid afforded the desired products in one pot.

  DOI：

  10.3987/com-09-11837

文献信息

• Catalytic Kinetic Resolution of Monohydrosilanes via Rhodium‐Catalyzed Enantioselective Intramolecular Hydrosilylation
  作者：Fei‐Hu Gou、Fei Ren、Yichen Wu、Peng Wang

  DOI：10.1002/anie.202404732

  日期：2024.6.17

  Catalytic kinetic resolution strategy was developed for the access of chiral Si-stereogenic silanes. By employing Rh-catalyzed intramolecular hydrosilylation, both dihydrobenzosilole-based organosilanes and monohydrosilane containing ortho-vinyl group could be prepared with high efficiency and good to excellent selectivity factors in one single operation.

  开发了催化动力学拆分策略来获得手性硅立体硅烷。通过采用Rh催化的分子内氢化硅烷化反应，可以在一次操作中高效地制备二氢苯并硅杂环基有机硅烷和含有邻乙烯基的一氢硅烷，并且具有良好至优异的选择性因子。